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Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice

Depression is a worldwide health problem. In the present study, we found that a dipeptide, tyrosyl leucine (Tyr-Leu, YL), administered orally, intracerebroventricularly, or intraperitoneally exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice. Y...

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Detalles Bibliográficos
Autores principales:	Mizushige, Takafumi, Uchida, Tomoki, Ohinata, Kousaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010778/ https://www.ncbi.nlm.nih.gov/pubmed/32042019 http://dx.doi.org/10.1038/s41598-020-59039-7

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