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Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer

Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the environmental signals from surrounding tissues and other immune cells. The pleiotropic function of ILCs in diverse contexts underpins its importance in the innate arm of immune system in human health and disease....

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Autores principales: An, Zhengwen, Flores-Borja, Fabian, Irshad, Sheeba, Deng, Jinhai, Ng, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010811/
https://www.ncbi.nlm.nih.gov/pubmed/32117199
http://dx.doi.org/10.3389/fimmu.2019.03111
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author An, Zhengwen
Flores-Borja, Fabian
Irshad, Sheeba
Deng, Jinhai
Ng, Tony
author_facet An, Zhengwen
Flores-Borja, Fabian
Irshad, Sheeba
Deng, Jinhai
Ng, Tony
author_sort An, Zhengwen
collection PubMed
description Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the environmental signals from surrounding tissues and other immune cells. The pleiotropic function of ILCs in diverse contexts underpins its importance in the innate arm of immune system in human health and disease. ILCs derive from common lymphoid progenitors but lack adaptive antigen receptors and functionally act as the innate counterpart to T-cell subsets. The classification of different subtypes is based on their distinct transcription factor requirement for development as well as signature cytokines that they produce. The discovery and subsequent characterization of ILCs over the past decade have mainly focused on the regulation of inflammation, tissue remodeling, and homeostasis, whereas the understanding of the multiple roles and mechanisms of ILCs in cancer is still limited. Emerging evidence of the potent immunomodulatory properties of ILCs in early host defense signifies a major advance in the use of ILCs as promising targets in cancer immunotherapy. In this review, we will decipher the non-exclusive roles of ILCs associated with both protumor and antitumor activities. We will also dissect the heterogeneity, plasticity, genetic evidence, and dysregulation in different cancer contexts, providing a comprehensive understanding of the complexity and diversity. These will have implications for the therapeutic targeting in cancer.
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spelling pubmed-70108112020-02-28 Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer An, Zhengwen Flores-Borja, Fabian Irshad, Sheeba Deng, Jinhai Ng, Tony Front Immunol Immunology Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the environmental signals from surrounding tissues and other immune cells. The pleiotropic function of ILCs in diverse contexts underpins its importance in the innate arm of immune system in human health and disease. ILCs derive from common lymphoid progenitors but lack adaptive antigen receptors and functionally act as the innate counterpart to T-cell subsets. The classification of different subtypes is based on their distinct transcription factor requirement for development as well as signature cytokines that they produce. The discovery and subsequent characterization of ILCs over the past decade have mainly focused on the regulation of inflammation, tissue remodeling, and homeostasis, whereas the understanding of the multiple roles and mechanisms of ILCs in cancer is still limited. Emerging evidence of the potent immunomodulatory properties of ILCs in early host defense signifies a major advance in the use of ILCs as promising targets in cancer immunotherapy. In this review, we will decipher the non-exclusive roles of ILCs associated with both protumor and antitumor activities. We will also dissect the heterogeneity, plasticity, genetic evidence, and dysregulation in different cancer contexts, providing a comprehensive understanding of the complexity and diversity. These will have implications for the therapeutic targeting in cancer. Frontiers Media S.A. 2020-02-04 /pmc/articles/PMC7010811/ /pubmed/32117199 http://dx.doi.org/10.3389/fimmu.2019.03111 Text en Copyright © 2020 An, Flores-Borja, Irshad, Deng and Ng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
An, Zhengwen
Flores-Borja, Fabian
Irshad, Sheeba
Deng, Jinhai
Ng, Tony
Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
title Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
title_full Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
title_fullStr Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
title_full_unstemmed Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
title_short Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
title_sort pleiotropic role and bidirectional immunomodulation of innate lymphoid cells in cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010811/
https://www.ncbi.nlm.nih.gov/pubmed/32117199
http://dx.doi.org/10.3389/fimmu.2019.03111
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