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Enhanced cortical responsiveness during natural sleep in freely behaving mice
Cortical networks exhibit large shifts in spontaneous dynamics depending on the vigilance state. Waking and rapid eye movement (REM) sleep are characterized by ongoing irregular activity of cortical neurons while during slow wave sleep (SWS) these neurons show synchronous alterations between silent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010820/ https://www.ncbi.nlm.nih.gov/pubmed/32042079 http://dx.doi.org/10.1038/s41598-020-59151-8 |
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author | Matsumoto, Sumire Ohyama, Kaoru Díaz, Javier Yanagisawa, Masashi Greene, Robert W. Vogt, Kaspar E. |
author_facet | Matsumoto, Sumire Ohyama, Kaoru Díaz, Javier Yanagisawa, Masashi Greene, Robert W. Vogt, Kaspar E. |
author_sort | Matsumoto, Sumire |
collection | PubMed |
description | Cortical networks exhibit large shifts in spontaneous dynamics depending on the vigilance state. Waking and rapid eye movement (REM) sleep are characterized by ongoing irregular activity of cortical neurons while during slow wave sleep (SWS) these neurons show synchronous alterations between silent (OFF) and active (ON) periods. The network dynamics underlying these phenomena are not fully understood. Additional information about the state of cortical networks can be obtained by evaluating evoked cortical responses during the sleep-wake cycle. We measured local field potentials (LFP) and multi-unit activity (MUA) in the cortex in response to repeated brief optogenetic stimulation of thalamocortical afferents. Both LFP and MUA responses were considerably increased in sleep compared to waking, with larger responses during SWS than during REM sleep. The strongly increased cortical response in SWS is discussed within the context of SWS-associated neuro-modulatory tone that may reduce feedforward inhibition. Responses to stimuli were larger during SWS-OFF periods than during SWS-ON periods. SWS responses showed clear daily fluctuation correlated to light-dark cycle, but no reaction to increased sleep need following sleep deprivation. Potential homeostatic synaptic plasticity was either absent or masked by large vigilance-state effects. |
format | Online Article Text |
id | pubmed-7010820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70108202020-02-21 Enhanced cortical responsiveness during natural sleep in freely behaving mice Matsumoto, Sumire Ohyama, Kaoru Díaz, Javier Yanagisawa, Masashi Greene, Robert W. Vogt, Kaspar E. Sci Rep Article Cortical networks exhibit large shifts in spontaneous dynamics depending on the vigilance state. Waking and rapid eye movement (REM) sleep are characterized by ongoing irregular activity of cortical neurons while during slow wave sleep (SWS) these neurons show synchronous alterations between silent (OFF) and active (ON) periods. The network dynamics underlying these phenomena are not fully understood. Additional information about the state of cortical networks can be obtained by evaluating evoked cortical responses during the sleep-wake cycle. We measured local field potentials (LFP) and multi-unit activity (MUA) in the cortex in response to repeated brief optogenetic stimulation of thalamocortical afferents. Both LFP and MUA responses were considerably increased in sleep compared to waking, with larger responses during SWS than during REM sleep. The strongly increased cortical response in SWS is discussed within the context of SWS-associated neuro-modulatory tone that may reduce feedforward inhibition. Responses to stimuli were larger during SWS-OFF periods than during SWS-ON periods. SWS responses showed clear daily fluctuation correlated to light-dark cycle, but no reaction to increased sleep need following sleep deprivation. Potential homeostatic synaptic plasticity was either absent or masked by large vigilance-state effects. Nature Publishing Group UK 2020-02-10 /pmc/articles/PMC7010820/ /pubmed/32042079 http://dx.doi.org/10.1038/s41598-020-59151-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Matsumoto, Sumire Ohyama, Kaoru Díaz, Javier Yanagisawa, Masashi Greene, Robert W. Vogt, Kaspar E. Enhanced cortical responsiveness during natural sleep in freely behaving mice |
title | Enhanced cortical responsiveness during natural sleep in freely behaving mice |
title_full | Enhanced cortical responsiveness during natural sleep in freely behaving mice |
title_fullStr | Enhanced cortical responsiveness during natural sleep in freely behaving mice |
title_full_unstemmed | Enhanced cortical responsiveness during natural sleep in freely behaving mice |
title_short | Enhanced cortical responsiveness during natural sleep in freely behaving mice |
title_sort | enhanced cortical responsiveness during natural sleep in freely behaving mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010820/ https://www.ncbi.nlm.nih.gov/pubmed/32042079 http://dx.doi.org/10.1038/s41598-020-59151-8 |
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