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Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases

The Epithelial-Mesenchymal Transition (EMT) is an important concept in understanding the processes of oncogenesis, especially with respect to the relationship between cell proliferation and metastatic properties such as spontaneous cell motility, chemotaxic migration and tissue invasion. EMT is now...

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Detalles Bibliográficos
Autor principal: Stone, Trevor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010924/
https://www.ncbi.nlm.nih.gov/pubmed/32117748
http://dx.doi.org/10.3389/fonc.2020.00094
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author Stone, Trevor W.
author_facet Stone, Trevor W.
author_sort Stone, Trevor W.
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description The Epithelial-Mesenchymal Transition (EMT) is an important concept in understanding the processes of oncogenesis, especially with respect to the relationship between cell proliferation and metastatic properties such as spontaneous cell motility, chemotaxic migration and tissue invasion. EMT is now recognized as a more complex phenomenon than an all-or-nothing event, in which different components of the EMT may have distinct roles in the physio-pathological regulation of cell function and which may in turn depend on differential interactions with cell constituents and metabolic products. This mini-review summarizes recent work on the induction of cancer properties in parallel with the presence of EMT activities in the presence of serine proteases, with the focus on those tumor suppressors known as “dependence” receptors such as neogenin and Deleted in Colorectal Cancer (DCC). It is concluded that various forms of partial EMT should be given more detailed investigation and consideration as the results could have valuable implications for the development of disease-specific and patient-specific therapies.
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spelling pubmed-70109242020-02-28 Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases Stone, Trevor W. Front Oncol Oncology The Epithelial-Mesenchymal Transition (EMT) is an important concept in understanding the processes of oncogenesis, especially with respect to the relationship between cell proliferation and metastatic properties such as spontaneous cell motility, chemotaxic migration and tissue invasion. EMT is now recognized as a more complex phenomenon than an all-or-nothing event, in which different components of the EMT may have distinct roles in the physio-pathological regulation of cell function and which may in turn depend on differential interactions with cell constituents and metabolic products. This mini-review summarizes recent work on the induction of cancer properties in parallel with the presence of EMT activities in the presence of serine proteases, with the focus on those tumor suppressors known as “dependence” receptors such as neogenin and Deleted in Colorectal Cancer (DCC). It is concluded that various forms of partial EMT should be given more detailed investigation and consideration as the results could have valuable implications for the development of disease-specific and patient-specific therapies. Frontiers Media S.A. 2020-02-04 /pmc/articles/PMC7010924/ /pubmed/32117748 http://dx.doi.org/10.3389/fonc.2020.00094 Text en Copyright © 2020 Stone. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Stone, Trevor W.
Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases
title Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases
title_full Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases
title_fullStr Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases
title_full_unstemmed Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases
title_short Dependence and Guidance Receptors—DCC and Neogenin—In Partial EMT and the Actions of Serine Proteases
title_sort dependence and guidance receptors—dcc and neogenin—in partial emt and the actions of serine proteases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010924/
https://www.ncbi.nlm.nih.gov/pubmed/32117748
http://dx.doi.org/10.3389/fonc.2020.00094
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