Cargando…
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
OBJECTIVE: The liver is regularly exposed to changing metabolic and inflammatory environments. It must sense and adapt to metabolic need while balancing resources required to protect itself from insult. Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α) is a transcriptiona...
Autores principales: | Léveillé, Mélissa, Besse-Patin, Aurèle, Jouvet, Nathalie, Gunes, Aysim, Sczelecki, Sarah, Jeromson, Stewart, Khan, Naveen P., Baldwin, Cindy, Dumouchel, Annie, Correia, Jorge C., Jannig, Paulo R., Boulais, Jonathan, Ruas, Jorge L., Estall, Jennifer L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011010/ https://www.ncbi.nlm.nih.gov/pubmed/32180561 http://dx.doi.org/10.1016/j.molmet.2020.01.004 |
Ejemplares similares
-
PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin
por: Besse-Patin, Aurèle, et al.
Publicado: (2019) -
PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes
por: Tuomainen, Tomi, et al.
Publicado: (2022) -
An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease
por: Besse-Patin, Aurèle, et al.
Publicado: (2014) -
Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome
por: Cyr, Yannick, et al.
Publicado: (2021) -
PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids
por: Oropeza, Daniel, et al.
Publicado: (2015)