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Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus
AIM: This study aimed to screen the common genes between celiac disease (CD) and type 1 diabetes mellitus to find critical ones. BACKGROUND: Celiac disease is a chronic autoimmune disorder which is correlated to type 1 diabetes mellitus (T1DM) in several molecular pathways. Understanding the clear c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011075/ https://www.ncbi.nlm.nih.gov/pubmed/32099612 |
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author | Rezaei-Tavirani, Sina Rostami-Nejad, Mohammad Vafaee, Reza Khalkhal, Ensieh Keramatinia, Aliasghar Ehsani-Ardakani, Mohammad Javad Razzaghi, Mohammadreza |
author_facet | Rezaei-Tavirani, Sina Rostami-Nejad, Mohammad Vafaee, Reza Khalkhal, Ensieh Keramatinia, Aliasghar Ehsani-Ardakani, Mohammad Javad Razzaghi, Mohammadreza |
author_sort | Rezaei-Tavirani, Sina |
collection | PubMed |
description | AIM: This study aimed to screen the common genes between celiac disease (CD) and type 1 diabetes mellitus to find critical ones. BACKGROUND: Celiac disease is a chronic autoimmune disorder which is correlated to type 1 diabetes mellitus (T1DM) in several molecular pathways. Understanding the clear common molecular mechanism of both diseases is of interest to scientists. METHODS: The related genes to the CD and T1DM were obtained from disease query of STRING and included in two separated PPI networks by Cytoscape software version 3.7.1. The networks were analyzed by network analyzer and the hub nodes were determined. The common hubs between the two networks were selected for further analysis and enriched via gene ontology using ClueGO plugin of Cytoscape software. Also, an action map was provided by Cluepedia application of Cytoscape software. RESULTS: Two separated networks of 2000 and 430 genes were constructed related to T1DM and CD, respectively. A total of 84 and 28 hubs were determined for T1DM and CD, respectively. There were 11 common hubs between the two networks. The first top hubs of Type 1 Diabetes Mellitus and CD networks were insulin (INS) and tumor necrosis factor (TNF), respectively. Also, 77 biological terms and pathways (in five clusters) were related to the common hubs. Action map revealed a close relationship between hubs. CONCLUSION: The result of this study indicated that TNF is key mediator of immune reactions in celiac disease and type 1 diabetes mellitus. |
format | Online Article Text |
id | pubmed-7011075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-70110752020-02-25 Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus Rezaei-Tavirani, Sina Rostami-Nejad, Mohammad Vafaee, Reza Khalkhal, Ensieh Keramatinia, Aliasghar Ehsani-Ardakani, Mohammad Javad Razzaghi, Mohammadreza Gastroenterol Hepatol Bed Bench Original Article AIM: This study aimed to screen the common genes between celiac disease (CD) and type 1 diabetes mellitus to find critical ones. BACKGROUND: Celiac disease is a chronic autoimmune disorder which is correlated to type 1 diabetes mellitus (T1DM) in several molecular pathways. Understanding the clear common molecular mechanism of both diseases is of interest to scientists. METHODS: The related genes to the CD and T1DM were obtained from disease query of STRING and included in two separated PPI networks by Cytoscape software version 3.7.1. The networks were analyzed by network analyzer and the hub nodes were determined. The common hubs between the two networks were selected for further analysis and enriched via gene ontology using ClueGO plugin of Cytoscape software. Also, an action map was provided by Cluepedia application of Cytoscape software. RESULTS: Two separated networks of 2000 and 430 genes were constructed related to T1DM and CD, respectively. A total of 84 and 28 hubs were determined for T1DM and CD, respectively. There were 11 common hubs between the two networks. The first top hubs of Type 1 Diabetes Mellitus and CD networks were insulin (INS) and tumor necrosis factor (TNF), respectively. Also, 77 biological terms and pathways (in five clusters) were related to the common hubs. Action map revealed a close relationship between hubs. CONCLUSION: The result of this study indicated that TNF is key mediator of immune reactions in celiac disease and type 1 diabetes mellitus. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC7011075/ /pubmed/32099612 Text en ©2019 RIGLD This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Rezaei-Tavirani, Sina Rostami-Nejad, Mohammad Vafaee, Reza Khalkhal, Ensieh Keramatinia, Aliasghar Ehsani-Ardakani, Mohammad Javad Razzaghi, Mohammadreza Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
title | Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
title_full | Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
title_fullStr | Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
title_full_unstemmed | Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
title_short | Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
title_sort | introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011075/ https://www.ncbi.nlm.nih.gov/pubmed/32099612 |
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