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A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways

Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization. We created transgenic Drosophila lines expressing the catalytic subunit CDTa to investig...

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Detalles Bibliográficos
Autores principales:	Schwartz, Ruth, Guichard, Annabel, Franc, Nathalie C., Roy, Sitara, Bier, Ethan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011083/ https://www.ncbi.nlm.nih.gov/pubmed/32058973 http://dx.doi.org/10.1016/j.isci.2020.100865

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