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Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators

Bioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physica...

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Detalles Bibliográficos
Autores principales: Wang, Baowei, Wang, Zhiwen, Chen, Tao, Zhao, Xueming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011095/
https://www.ncbi.nlm.nih.gov/pubmed/32117906
http://dx.doi.org/10.3389/fbioe.2020.00007
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author Wang, Baowei
Wang, Zhiwen
Chen, Tao
Zhao, Xueming
author_facet Wang, Baowei
Wang, Zhiwen
Chen, Tao
Zhao, Xueming
author_sort Wang, Baowei
collection PubMed
description Bioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physical structure of the control system. After the introduction of digital computers to bioreactor process control, a hierarchical structure control system (HSCS) for bioreactors has become the dominant physical structure, having high efficiency and robustness. However, inherent drawbacks of the HSCS for bioreactors have produced a need for a more consolidated solution of the control system. With the fast progress in sensors, machinery, and information technology, the development of a flat organizational control system (FOCS) for bioreactors based on parallel distributed smart sensors and actuators may provide a more concise solution for process control in bioreactors. Here, we review the evolution of the physical structure of bioreactor control systems and discuss the properties of the novel FOCS for bioreactors and related smart sensors and actuators and their application circumstances, with the hope of further improving the efficiency, robustness, and economics of bioprocess control.
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spelling pubmed-70110952020-02-28 Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators Wang, Baowei Wang, Zhiwen Chen, Tao Zhao, Xueming Front Bioeng Biotechnol Bioengineering and Biotechnology Bioreactors of various forms have been widely used in environmental protection, healthcare, industrial biotechnology, and space exploration. Robust demand in the field stimulated the development of novel designs of bioreactor geometries and process control strategies and the evolution of the physical structure of the control system. After the introduction of digital computers to bioreactor process control, a hierarchical structure control system (HSCS) for bioreactors has become the dominant physical structure, having high efficiency and robustness. However, inherent drawbacks of the HSCS for bioreactors have produced a need for a more consolidated solution of the control system. With the fast progress in sensors, machinery, and information technology, the development of a flat organizational control system (FOCS) for bioreactors based on parallel distributed smart sensors and actuators may provide a more concise solution for process control in bioreactors. Here, we review the evolution of the physical structure of bioreactor control systems and discuss the properties of the novel FOCS for bioreactors and related smart sensors and actuators and their application circumstances, with the hope of further improving the efficiency, robustness, and economics of bioprocess control. Frontiers Media S.A. 2020-02-04 /pmc/articles/PMC7011095/ /pubmed/32117906 http://dx.doi.org/10.3389/fbioe.2020.00007 Text en Copyright © 2020 Wang, Wang, Chen and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Baowei
Wang, Zhiwen
Chen, Tao
Zhao, Xueming
Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
title Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
title_full Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
title_fullStr Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
title_full_unstemmed Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
title_short Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators
title_sort development of novel bioreactor control systems based on smart sensors and actuators
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011095/
https://www.ncbi.nlm.nih.gov/pubmed/32117906
http://dx.doi.org/10.3389/fbioe.2020.00007
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