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Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma

Increasing evidence has verified that small nucleolar RNAs (snoRNAs) play significant roles in tumorigenesis and exhibit prognostic value in clinical practice. In the study, we analysed the expression profile and clinical relevance of snoRNAs from TCGA database including 530 ccRCC (clear cell renal...

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Autores principales: Zhao, Yanyun, Yan, Yuanyuan, Ma, Rong, Lv, Xuemei, Zhang, Liwen, Wang, Jinlong, Zhu, Wenjing, Zhao, Lan, Jiang, Longyang, Zhao, Lin, Wen, Lijie, Yang, Bo, Chen, Yuzong, He, Miao, Liu, Mingyan, Wei, Minjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011154/
https://www.ncbi.nlm.nih.gov/pubmed/31943775
http://dx.doi.org/10.1111/jcmm.14886
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author Zhao, Yanyun
Yan, Yuanyuan
Ma, Rong
Lv, Xuemei
Zhang, Liwen
Wang, Jinlong
Zhu, Wenjing
Zhao, Lan
Jiang, Longyang
Zhao, Lin
Wen, Lijie
Yang, Bo
Chen, Yuzong
He, Miao
Liu, Mingyan
Wei, Minjie
author_facet Zhao, Yanyun
Yan, Yuanyuan
Ma, Rong
Lv, Xuemei
Zhang, Liwen
Wang, Jinlong
Zhu, Wenjing
Zhao, Lan
Jiang, Longyang
Zhao, Lin
Wen, Lijie
Yang, Bo
Chen, Yuzong
He, Miao
Liu, Mingyan
Wei, Minjie
author_sort Zhao, Yanyun
collection PubMed
description Increasing evidence has verified that small nucleolar RNAs (snoRNAs) play significant roles in tumorigenesis and exhibit prognostic value in clinical practice. In the study, we analysed the expression profile and clinical relevance of snoRNAs from TCGA database including 530 ccRCC (clear cell renal cell carcinoma) and 72 control cases. By using univariate and multivariate Cox analysis, we established a six‐snoRNA signature and divided patients into high‐risk or low‐risk groups. We found patients in high‐risk group had significantly shorter overall survival and recurrence‐free survival than those in low‐risk group in test series, validation series and entire series by Kaplan‐Meier analysis. We also confirmed this signature had a great accuracy and specificity in 64 clinical tissue cases and 50 serum samples. Then, depending on receiver operating characteristic curve analysis we found the six‐snoRNA signature was an superior indicator better than conventional clinical factors (AUC = 0.732). Furthermore, combining the signature with TNM stage or Fuhrman grade were the optimal indicators (AUC = 0.792; AUC = 0.800) and processed the clinical applied value for ccRCC. Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC. In general, our study established a six‐snoRNA signature as an independent and superior diagnosis and prognosis indicator for ccRCC.
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spelling pubmed-70111542020-02-18 Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma Zhao, Yanyun Yan, Yuanyuan Ma, Rong Lv, Xuemei Zhang, Liwen Wang, Jinlong Zhu, Wenjing Zhao, Lan Jiang, Longyang Zhao, Lin Wen, Lijie Yang, Bo Chen, Yuzong He, Miao Liu, Mingyan Wei, Minjie J Cell Mol Med Original Articles Increasing evidence has verified that small nucleolar RNAs (snoRNAs) play significant roles in tumorigenesis and exhibit prognostic value in clinical practice. In the study, we analysed the expression profile and clinical relevance of snoRNAs from TCGA database including 530 ccRCC (clear cell renal cell carcinoma) and 72 control cases. By using univariate and multivariate Cox analysis, we established a six‐snoRNA signature and divided patients into high‐risk or low‐risk groups. We found patients in high‐risk group had significantly shorter overall survival and recurrence‐free survival than those in low‐risk group in test series, validation series and entire series by Kaplan‐Meier analysis. We also confirmed this signature had a great accuracy and specificity in 64 clinical tissue cases and 50 serum samples. Then, depending on receiver operating characteristic curve analysis we found the six‐snoRNA signature was an superior indicator better than conventional clinical factors (AUC = 0.732). Furthermore, combining the signature with TNM stage or Fuhrman grade were the optimal indicators (AUC = 0.792; AUC = 0.800) and processed the clinical applied value for ccRCC. Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC. In general, our study established a six‐snoRNA signature as an independent and superior diagnosis and prognosis indicator for ccRCC. John Wiley and Sons Inc. 2020-01-14 2020-02 /pmc/articles/PMC7011154/ /pubmed/31943775 http://dx.doi.org/10.1111/jcmm.14886 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhao, Yanyun
Yan, Yuanyuan
Ma, Rong
Lv, Xuemei
Zhang, Liwen
Wang, Jinlong
Zhu, Wenjing
Zhao, Lan
Jiang, Longyang
Zhao, Lin
Wen, Lijie
Yang, Bo
Chen, Yuzong
He, Miao
Liu, Mingyan
Wei, Minjie
Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
title Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
title_full Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
title_fullStr Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
title_full_unstemmed Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
title_short Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
title_sort expression signature of six‐snorna serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011154/
https://www.ncbi.nlm.nih.gov/pubmed/31943775
http://dx.doi.org/10.1111/jcmm.14886
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