Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion

[Image: see text] A robust nickel-catalyzed oxidative isocyanide insertion/C–H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i....

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Detalles Bibliográficos
Autores principales: Collet, Jurriën W., Morel, Bénédicte, Lin, Hung-Chien, Roose, Thomas R., Mampuys, Pieter, Orru, Romano V. A., Ruijter, Eelco, Maes, Bert U. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011176/
https://www.ncbi.nlm.nih.gov/pubmed/31942797
http://dx.doi.org/10.1021/acs.orglett.9b04387

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