The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma

Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient...

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Autores principales: Naro, Gillian R., Noverati, Nicholas, Craig, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011394/
https://www.ncbi.nlm.nih.gov/pubmed/32082381
http://dx.doi.org/10.1155/2020/7981609
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author Naro, Gillian R.
Noverati, Nicholas
Craig, Timothy
author_facet Naro, Gillian R.
Noverati, Nicholas
Craig, Timothy
author_sort Naro, Gillian R.
collection PubMed
description Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient's morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB.
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spelling pubmed-70113942020-02-20 The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma Naro, Gillian R. Noverati, Nicholas Craig, Timothy Case Rep Med Case Report Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient's morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB. Hindawi 2020-01-28 /pmc/articles/PMC7011394/ /pubmed/32082381 http://dx.doi.org/10.1155/2020/7981609 Text en Copyright © 2020 Gillian R. Naro et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Naro, Gillian R.
Noverati, Nicholas
Craig, Timothy
The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
title The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
title_full The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
title_fullStr The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
title_full_unstemmed The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
title_short The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
title_sort role of c1-esterase inhibitors in the management of vasogenic edema in glioblastoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011394/
https://www.ncbi.nlm.nih.gov/pubmed/32082381
http://dx.doi.org/10.1155/2020/7981609
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