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Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

BACKGROUND: Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the...

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Autores principales: Perrott, Sarah, Laurie, Kirsten, Laws, Kirsten, Johnes, Annie, Miedzybrodzka, Zosia, Samuel, Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011562/
https://www.ncbi.nlm.nih.gov/pubmed/32041565
http://dx.doi.org/10.1186/s12885-020-6606-0
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author Perrott, Sarah
Laurie, Kirsten
Laws, Kirsten
Johnes, Annie
Miedzybrodzka, Zosia
Samuel, Leslie
author_facet Perrott, Sarah
Laurie, Kirsten
Laws, Kirsten
Johnes, Annie
Miedzybrodzka, Zosia
Samuel, Leslie
author_sort Perrott, Sarah
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. METHODS: A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005 and 2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral. RESULTS: Data from 345 patients (age range 22–54 years) were identified. The one year, five year and overall survival rates were found to be 89, 63 and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetic services. Microsatellite instability (MSI) was identified in 14% of those referred. CONCLUSION: Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome.
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spelling pubmed-70115622020-02-18 Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics Perrott, Sarah Laurie, Kirsten Laws, Kirsten Johnes, Annie Miedzybrodzka, Zosia Samuel, Leslie BMC Cancer Research Article BACKGROUND: Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. METHODS: A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005 and 2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral. RESULTS: Data from 345 patients (age range 22–54 years) were identified. The one year, five year and overall survival rates were found to be 89, 63 and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetic services. Microsatellite instability (MSI) was identified in 14% of those referred. CONCLUSION: Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome. BioMed Central 2020-02-10 /pmc/articles/PMC7011562/ /pubmed/32041565 http://dx.doi.org/10.1186/s12885-020-6606-0 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Perrott, Sarah
Laurie, Kirsten
Laws, Kirsten
Johnes, Annie
Miedzybrodzka, Zosia
Samuel, Leslie
Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
title Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
title_full Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
title_fullStr Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
title_full_unstemmed Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
title_short Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics
title_sort young-onset colorectal cancer in the north east of scotland: survival, clinico-pathological features and genetics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011562/
https://www.ncbi.nlm.nih.gov/pubmed/32041565
http://dx.doi.org/10.1186/s12885-020-6606-0
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