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Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)

Background: Neurological disorders (ND) have a profound consequence on human productivity, quality of life and survival. There are limited data on the burden of ND in Tanzania due to insufficient coverage of civil and vital registration systems. Objectives: This study was conducted to estimate morta...

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Autores principales: Levira, Francis, Newton, Charles R., Masanja, Honorati, Odermatt, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011788/
https://www.ncbi.nlm.nih.gov/pubmed/31144608
http://dx.doi.org/10.1080/16549716.2019.1596378
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author Levira, Francis
Newton, Charles R.
Masanja, Honorati
Odermatt, Peter
author_facet Levira, Francis
Newton, Charles R.
Masanja, Honorati
Odermatt, Peter
author_sort Levira, Francis
collection PubMed
description Background: Neurological disorders (ND) have a profound consequence on human productivity, quality of life and survival. There are limited data on the burden of ND in Tanzania due to insufficient coverage of civil and vital registration systems. Objectives: This study was conducted to estimate mortality of ND in all ages in Tanzania using data from the Sample Vital Registration with Verbal Autopsy (SAVVY) study. Methods: Multistage random sampling was employed to select 23 districts, 1397 census enumeration areas and 154,603 households. During the baseline survey conducted between 2011 and 2014, deaths which occurred 12 months prior to the baseline survey were documented followed by verbal autopsy interviews. Causes of death were certified using International Classification of Diseases. Results: The baseline survey enrolled a total of 650,864 residents. A total of 6645 deaths were reported to have occurred 12 months before the date of survey. Death certification was available for 5225 (79%) deaths. The leading causes of death were cerebrovascular diseases with a cause-specific mortality fraction (CSMF) of 1.64% (95% CI: 1.30–1.99) and 3.82% (95% CI: 2.92–4.72) in all ages and adults older than 50 years, respectively. Stroke accounted for 92% of all cerebrovascular deaths. Mortality of epilepsy was estimated with a CSMF of 0.94% (95% CI: 0.68–1.20); meningitis with a CSMF of 0.80% (95% CI: 0.56–1.04); cerebral palsy and other paralytic syndromes with a CSMF of 0.46% (95% CI: 0.27–0.65); and intrauterine hypoxia in neonates with a CSMF of 2.06% (95% CI: 1.12–3.01). Overall, mortality of ND was estimated with a CSMF of 4.99% (95% CI: 4.40–5.58). Conclusions: The SAVVY survey provides estimates of mortality burden of ND in Tanzania. The study provides a basis for monitoring trends of ND and contributes to advancing knowledge of the burden of diseases. Integrating morbidities measures into the SAVVY design will provide comprehensive measures of burden of ND taking into account lifetime disabilities created by ND.
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spelling pubmed-70117882020-02-24 Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY) Levira, Francis Newton, Charles R. Masanja, Honorati Odermatt, Peter Glob Health Action Original Article Background: Neurological disorders (ND) have a profound consequence on human productivity, quality of life and survival. There are limited data on the burden of ND in Tanzania due to insufficient coverage of civil and vital registration systems. Objectives: This study was conducted to estimate mortality of ND in all ages in Tanzania using data from the Sample Vital Registration with Verbal Autopsy (SAVVY) study. Methods: Multistage random sampling was employed to select 23 districts, 1397 census enumeration areas and 154,603 households. During the baseline survey conducted between 2011 and 2014, deaths which occurred 12 months prior to the baseline survey were documented followed by verbal autopsy interviews. Causes of death were certified using International Classification of Diseases. Results: The baseline survey enrolled a total of 650,864 residents. A total of 6645 deaths were reported to have occurred 12 months before the date of survey. Death certification was available for 5225 (79%) deaths. The leading causes of death were cerebrovascular diseases with a cause-specific mortality fraction (CSMF) of 1.64% (95% CI: 1.30–1.99) and 3.82% (95% CI: 2.92–4.72) in all ages and adults older than 50 years, respectively. Stroke accounted for 92% of all cerebrovascular deaths. Mortality of epilepsy was estimated with a CSMF of 0.94% (95% CI: 0.68–1.20); meningitis with a CSMF of 0.80% (95% CI: 0.56–1.04); cerebral palsy and other paralytic syndromes with a CSMF of 0.46% (95% CI: 0.27–0.65); and intrauterine hypoxia in neonates with a CSMF of 2.06% (95% CI: 1.12–3.01). Overall, mortality of ND was estimated with a CSMF of 4.99% (95% CI: 4.40–5.58). Conclusions: The SAVVY survey provides estimates of mortality burden of ND in Tanzania. The study provides a basis for monitoring trends of ND and contributes to advancing knowledge of the burden of diseases. Integrating morbidities measures into the SAVVY design will provide comprehensive measures of burden of ND taking into account lifetime disabilities created by ND. Taylor & Francis 2019-05-30 /pmc/articles/PMC7011788/ /pubmed/31144608 http://dx.doi.org/10.1080/16549716.2019.1596378 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Levira, Francis
Newton, Charles R.
Masanja, Honorati
Odermatt, Peter
Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)
title Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)
title_full Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)
title_fullStr Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)
title_full_unstemmed Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)
title_short Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY)
title_sort mortality of neurological disorders in tanzania: analysis of baseline data from sample vital registration with verbal autopsy (savvy)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011788/
https://www.ncbi.nlm.nih.gov/pubmed/31144608
http://dx.doi.org/10.1080/16549716.2019.1596378
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