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In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria

Context: Malaria remains one of the prevalent infectious diseases worldwide. Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (PfDXR) plays a role in isoprenoid biosynthesis in the malaria parasite, making this parasite enzyme an attractive target for antimalarial drug design. F...

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Detalles Bibliográficos
Autores principales:	Wadood, Abdul, Ghufran, Mehreen, Hassan, Syed Fahad, Khan, Huma, Azam, Syed Sikandar, Rashid, Umer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011789/ https://www.ncbi.nlm.nih.gov/pubmed/27650666 http://dx.doi.org/10.1080/13880209.2016.1225778

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