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Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies
BACKGROUND: The risk stratification of coronary heart disease (CHD) and/or heart failure (HF) patients with easily measured electrocardiographic markers is of clinical importance. The aim of this meta‐analysis is to indicate whether increased QT dispersion (QTd) is associated with fatal and nonfatal...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011802/ https://www.ncbi.nlm.nih.gov/pubmed/32071628 http://dx.doi.org/10.1002/joa3.12253 |
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author | Bazoukis, George Yeung, Cynthia Wui Hang Ho, Ryan Varrias, Dimitrios Papadatos, Stamatis Lee, Sharen Ho Christien Li, Ka Sakellaropoulou, Antigoni Saplaouras, Athanasios Kitsoulis, Panagiotis Vlachos, Konstantinos Lampropoulos, Konstantinos Thomopoulos, Costas Letsas, Konstantinos P. Liu, Tong Tse, Gary |
author_facet | Bazoukis, George Yeung, Cynthia Wui Hang Ho, Ryan Varrias, Dimitrios Papadatos, Stamatis Lee, Sharen Ho Christien Li, Ka Sakellaropoulou, Antigoni Saplaouras, Athanasios Kitsoulis, Panagiotis Vlachos, Konstantinos Lampropoulos, Konstantinos Thomopoulos, Costas Letsas, Konstantinos P. Liu, Tong Tse, Gary |
author_sort | Bazoukis, George |
collection | PubMed |
description | BACKGROUND: The risk stratification of coronary heart disease (CHD) and/or heart failure (HF) patients with easily measured electrocardiographic markers is of clinical importance. The aim of this meta‐analysis is to indicate whether increased QT dispersion (QTd) is associated with fatal and nonfatal outcomes in patients with CHD and/or HF. METHODS: We systematically searched MEDLINE and Cochrane databases without restrictions until August 15, 2018 using the keyword “QT dispersion”. Studies including data on the association between QTd and all‐cause mortality, sudden cardiac death (SCD) or arrhythmic events in patients with HF and/or CHD were classified as eligible. RESULTS: In the analysis including patients with CHD and/or HF, we found that QTd did not differ significantly in patients with SCD compared to no SCD patients while QTd was significantly greater in the group of all‐cause mortality patients and in patients who experienced a sustained ventricular arrhythmia. Subgroup analysis showed that in myocardial infarction studies, QTd was significantly higher in patients with an arrhythmic event compared to arrhythmic event‐free patients while a nonsignificant difference was found in QTd in patients who died from any cause compared to survivors. Similarly, in HF patients, the QTd was significantly greater in patients with an arrhythmic event while a nonsignificant difference was found regarding all‐cause mortality and SCD outcomes. CONCLUSIONS: QTd has a prognostic role for stratifying myocardial infarction or HF patients who are at higher risk of arrhythmic events. However, no prognostic role was found regarding all‐cause mortality or SCD in this patient population. |
format | Online Article Text |
id | pubmed-7011802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70118022020-02-18 Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies Bazoukis, George Yeung, Cynthia Wui Hang Ho, Ryan Varrias, Dimitrios Papadatos, Stamatis Lee, Sharen Ho Christien Li, Ka Sakellaropoulou, Antigoni Saplaouras, Athanasios Kitsoulis, Panagiotis Vlachos, Konstantinos Lampropoulos, Konstantinos Thomopoulos, Costas Letsas, Konstantinos P. Liu, Tong Tse, Gary J Arrhythm Original Articles BACKGROUND: The risk stratification of coronary heart disease (CHD) and/or heart failure (HF) patients with easily measured electrocardiographic markers is of clinical importance. The aim of this meta‐analysis is to indicate whether increased QT dispersion (QTd) is associated with fatal and nonfatal outcomes in patients with CHD and/or HF. METHODS: We systematically searched MEDLINE and Cochrane databases without restrictions until August 15, 2018 using the keyword “QT dispersion”. Studies including data on the association between QTd and all‐cause mortality, sudden cardiac death (SCD) or arrhythmic events in patients with HF and/or CHD were classified as eligible. RESULTS: In the analysis including patients with CHD and/or HF, we found that QTd did not differ significantly in patients with SCD compared to no SCD patients while QTd was significantly greater in the group of all‐cause mortality patients and in patients who experienced a sustained ventricular arrhythmia. Subgroup analysis showed that in myocardial infarction studies, QTd was significantly higher in patients with an arrhythmic event compared to arrhythmic event‐free patients while a nonsignificant difference was found in QTd in patients who died from any cause compared to survivors. Similarly, in HF patients, the QTd was significantly greater in patients with an arrhythmic event while a nonsignificant difference was found regarding all‐cause mortality and SCD outcomes. CONCLUSIONS: QTd has a prognostic role for stratifying myocardial infarction or HF patients who are at higher risk of arrhythmic events. However, no prognostic role was found regarding all‐cause mortality or SCD in this patient population. John Wiley and Sons Inc. 2019-11-11 /pmc/articles/PMC7011802/ /pubmed/32071628 http://dx.doi.org/10.1002/joa3.12253 Text en © 2019 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Bazoukis, George Yeung, Cynthia Wui Hang Ho, Ryan Varrias, Dimitrios Papadatos, Stamatis Lee, Sharen Ho Christien Li, Ka Sakellaropoulou, Antigoni Saplaouras, Athanasios Kitsoulis, Panagiotis Vlachos, Konstantinos Lampropoulos, Konstantinos Thomopoulos, Costas Letsas, Konstantinos P. Liu, Tong Tse, Gary Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies |
title | Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies |
title_full | Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies |
title_fullStr | Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies |
title_full_unstemmed | Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies |
title_short | Association of QT dispersion with mortality and arrhythmic events—A meta‐analysis of observational studies |
title_sort | association of qt dispersion with mortality and arrhythmic events—a meta‐analysis of observational studies |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011802/ https://www.ncbi.nlm.nih.gov/pubmed/32071628 http://dx.doi.org/10.1002/joa3.12253 |
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