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Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart
BACKGROUND: We examined risk factors for development of ventricular tachycardia (VT) in pediatric patients with ventricular premature contractions (VPCs) and a structurally normal heart. METHODS: The subjects were 81 844 first graders and 88 244 seventh graders of Kagoshima City School‐based cardiov...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011805/ https://www.ncbi.nlm.nih.gov/pubmed/32071631 http://dx.doi.org/10.1002/joa3.12286 |
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author | Nomura, Yuichi Seki, Syunji Hazeki, Daisuke Ueno, Kentaro Tanaka, Yuji Masuda, Kiminori Nishibatake, Makoto Yoshinaga, Masao |
author_facet | Nomura, Yuichi Seki, Syunji Hazeki, Daisuke Ueno, Kentaro Tanaka, Yuji Masuda, Kiminori Nishibatake, Makoto Yoshinaga, Masao |
author_sort | Nomura, Yuichi |
collection | PubMed |
description | BACKGROUND: We examined risk factors for development of ventricular tachycardia (VT) in pediatric patients with ventricular premature contractions (VPCs) and a structurally normal heart. METHODS: The subjects were 81 844 first graders and 88 244 seventh graders of Kagoshima City School‐based cardiovascular screening (SCV‐screening) between 2001 and 2015. We retrospectively reviewed the clinical data of students who were diagnosed as having VPC. RESULTS: Ventricular premature contractions were observed in 134 first graders (0.16%) and 270 seventh graders (0.31%). On the screening electrocardiograms (ECGs), 43 patients (11%) showed bi‐/trigemini, three patients (0.7%) showed a couplet, and one patient showed VT. We obtained 166 patients' follow‐up information and evaluated 59 patients (36%) as improved, 97 patients (58%) as no change, and 10 patients (6%) as worsened (couplets, five; triplets, two; VT, three). We assumed that these worsened patients have risk factors for development of VT. Comparing the findings of SCV‐screening ECGs of risk patients with the others, a significant difference was observed only in the number of VPCs (per 10 seconds) (mean ± SD; 4.3 ± 2.6 vs 1.8 ± 1.4, P < .0001). A logistic regression analysis revealed that the number of VPCs was significant (P < .001, odds ratio; 2.01, 95% confidence intervals; 1.46‐2.93). Receiver operating characteristics analysis showed an adequate cut‐off number of three VPCs for the risk, the sensitivity was 89% and the specificity was 77%. CONCLUSIONS: Of the patients with VPC and a structurally normal heart, a few patients developed VT. Careful observation is important in patients who had three or more VPCs on SCV‐screening ECG. |
format | Online Article Text |
id | pubmed-7011805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70118052020-02-18 Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart Nomura, Yuichi Seki, Syunji Hazeki, Daisuke Ueno, Kentaro Tanaka, Yuji Masuda, Kiminori Nishibatake, Makoto Yoshinaga, Masao J Arrhythm Original Articles BACKGROUND: We examined risk factors for development of ventricular tachycardia (VT) in pediatric patients with ventricular premature contractions (VPCs) and a structurally normal heart. METHODS: The subjects were 81 844 first graders and 88 244 seventh graders of Kagoshima City School‐based cardiovascular screening (SCV‐screening) between 2001 and 2015. We retrospectively reviewed the clinical data of students who were diagnosed as having VPC. RESULTS: Ventricular premature contractions were observed in 134 first graders (0.16%) and 270 seventh graders (0.31%). On the screening electrocardiograms (ECGs), 43 patients (11%) showed bi‐/trigemini, three patients (0.7%) showed a couplet, and one patient showed VT. We obtained 166 patients' follow‐up information and evaluated 59 patients (36%) as improved, 97 patients (58%) as no change, and 10 patients (6%) as worsened (couplets, five; triplets, two; VT, three). We assumed that these worsened patients have risk factors for development of VT. Comparing the findings of SCV‐screening ECGs of risk patients with the others, a significant difference was observed only in the number of VPCs (per 10 seconds) (mean ± SD; 4.3 ± 2.6 vs 1.8 ± 1.4, P < .0001). A logistic regression analysis revealed that the number of VPCs was significant (P < .001, odds ratio; 2.01, 95% confidence intervals; 1.46‐2.93). Receiver operating characteristics analysis showed an adequate cut‐off number of three VPCs for the risk, the sensitivity was 89% and the specificity was 77%. CONCLUSIONS: Of the patients with VPC and a structurally normal heart, a few patients developed VT. Careful observation is important in patients who had three or more VPCs on SCV‐screening ECG. John Wiley and Sons Inc. 2019-12-16 /pmc/articles/PMC7011805/ /pubmed/32071631 http://dx.doi.org/10.1002/joa3.12286 Text en © 2019 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Nomura, Yuichi Seki, Syunji Hazeki, Daisuke Ueno, Kentaro Tanaka, Yuji Masuda, Kiminori Nishibatake, Makoto Yoshinaga, Masao Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
title | Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
title_full | Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
title_fullStr | Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
title_full_unstemmed | Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
title_short | Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
title_sort | risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011805/ https://www.ncbi.nlm.nih.gov/pubmed/32071631 http://dx.doi.org/10.1002/joa3.12286 |
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