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The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis

Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the progn...

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Autores principales: Jang, Ha Nee, Park, Hee Jung, Cho, Hyun Seop, Bae, Eunjin, Lee, Tae Won, Chang, Se-Ho, Park, Dong Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011874/
https://www.ncbi.nlm.nih.gov/pubmed/30741615
http://dx.doi.org/10.1080/0886022X.2018.1491405
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author Jang, Ha Nee
Park, Hee Jung
Cho, Hyun Seop
Bae, Eunjin
Lee, Tae Won
Chang, Se-Ho
Park, Dong Jun
author_facet Jang, Ha Nee
Park, Hee Jung
Cho, Hyun Seop
Bae, Eunjin
Lee, Tae Won
Chang, Se-Ho
Park, Dong Jun
author_sort Jang, Ha Nee
collection PubMed
description Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the prognosis. We used LODS score to predict prognosis of AKA. We retrospectively reviewed the medical records of 46 patients who were diagnosed as AKA in our hospital. The mean LODS score was 6.3. The probability of mortality based on the LODS score was 36.6%, and 16 patients (34.5%) did, in fact, die. The total LODS score and lactate dehydrogenase (LDH) were significantly higher in the non-survival group. Prothrombin activity, serum platelet number, and the serum albumin levels were significantly higher in the survival group. We found significant correlations between the LODS score and arterial pH, the albumin level, and the LDH concentration. Multivariate analysis showed that the serum albumin and LDH levels were independently associated with survival in AKA patients. AKA patients suffered high-level mortality and the LODS score was an accurate predictor of prognosis. Clinicians may use the LODS score to this end.
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spelling pubmed-70118742020-02-24 The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis Jang, Ha Nee Park, Hee Jung Cho, Hyun Seop Bae, Eunjin Lee, Tae Won Chang, Se-Ho Park, Dong Jun Ren Fail Clinical Study Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the prognosis. We used LODS score to predict prognosis of AKA. We retrospectively reviewed the medical records of 46 patients who were diagnosed as AKA in our hospital. The mean LODS score was 6.3. The probability of mortality based on the LODS score was 36.6%, and 16 patients (34.5%) did, in fact, die. The total LODS score and lactate dehydrogenase (LDH) were significantly higher in the non-survival group. Prothrombin activity, serum platelet number, and the serum albumin levels were significantly higher in the survival group. We found significant correlations between the LODS score and arterial pH, the albumin level, and the LDH concentration. Multivariate analysis showed that the serum albumin and LDH levels were independently associated with survival in AKA patients. AKA patients suffered high-level mortality and the LODS score was an accurate predictor of prognosis. Clinicians may use the LODS score to this end. Taylor & Francis 2019-02-11 /pmc/articles/PMC7011874/ /pubmed/30741615 http://dx.doi.org/10.1080/0886022X.2018.1491405 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Jang, Ha Nee
Park, Hee Jung
Cho, Hyun Seop
Bae, Eunjin
Lee, Tae Won
Chang, Se-Ho
Park, Dong Jun
The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
title The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
title_full The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
title_fullStr The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
title_full_unstemmed The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
title_short The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
title_sort logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011874/
https://www.ncbi.nlm.nih.gov/pubmed/30741615
http://dx.doi.org/10.1080/0886022X.2018.1491405
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