Cargando…
The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis
Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the progn...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011874/ https://www.ncbi.nlm.nih.gov/pubmed/30741615 http://dx.doi.org/10.1080/0886022X.2018.1491405 |
_version_ | 1783496144197779456 |
---|---|
author | Jang, Ha Nee Park, Hee Jung Cho, Hyun Seop Bae, Eunjin Lee, Tae Won Chang, Se-Ho Park, Dong Jun |
author_facet | Jang, Ha Nee Park, Hee Jung Cho, Hyun Seop Bae, Eunjin Lee, Tae Won Chang, Se-Ho Park, Dong Jun |
author_sort | Jang, Ha Nee |
collection | PubMed |
description | Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the prognosis. We used LODS score to predict prognosis of AKA. We retrospectively reviewed the medical records of 46 patients who were diagnosed as AKA in our hospital. The mean LODS score was 6.3. The probability of mortality based on the LODS score was 36.6%, and 16 patients (34.5%) did, in fact, die. The total LODS score and lactate dehydrogenase (LDH) were significantly higher in the non-survival group. Prothrombin activity, serum platelet number, and the serum albumin levels were significantly higher in the survival group. We found significant correlations between the LODS score and arterial pH, the albumin level, and the LDH concentration. Multivariate analysis showed that the serum albumin and LDH levels were independently associated with survival in AKA patients. AKA patients suffered high-level mortality and the LODS score was an accurate predictor of prognosis. Clinicians may use the LODS score to this end. |
format | Online Article Text |
id | pubmed-7011874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-70118742020-02-24 The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis Jang, Ha Nee Park, Hee Jung Cho, Hyun Seop Bae, Eunjin Lee, Tae Won Chang, Se-Ho Park, Dong Jun Ren Fail Clinical Study Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA. It is known that the logistic organ dysfunction system (LODS) score is an objective and useful index to predict the prognosis. We used LODS score to predict prognosis of AKA. We retrospectively reviewed the medical records of 46 patients who were diagnosed as AKA in our hospital. The mean LODS score was 6.3. The probability of mortality based on the LODS score was 36.6%, and 16 patients (34.5%) did, in fact, die. The total LODS score and lactate dehydrogenase (LDH) were significantly higher in the non-survival group. Prothrombin activity, serum platelet number, and the serum albumin levels were significantly higher in the survival group. We found significant correlations between the LODS score and arterial pH, the albumin level, and the LDH concentration. Multivariate analysis showed that the serum albumin and LDH levels were independently associated with survival in AKA patients. AKA patients suffered high-level mortality and the LODS score was an accurate predictor of prognosis. Clinicians may use the LODS score to this end. Taylor & Francis 2019-02-11 /pmc/articles/PMC7011874/ /pubmed/30741615 http://dx.doi.org/10.1080/0886022X.2018.1491405 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Jang, Ha Nee Park, Hee Jung Cho, Hyun Seop Bae, Eunjin Lee, Tae Won Chang, Se-Ho Park, Dong Jun The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
title | The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
title_full | The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
title_fullStr | The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
title_full_unstemmed | The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
title_short | The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
title_sort | logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011874/ https://www.ncbi.nlm.nih.gov/pubmed/30741615 http://dx.doi.org/10.1080/0886022X.2018.1491405 |
work_keys_str_mv | AT janghanee thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT parkheejung thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT chohyunseop thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT baeeunjin thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT leetaewon thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT changseho thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT parkdongjun thelogisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT janghanee logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT parkheejung logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT chohyunseop logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT baeeunjin logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT leetaewon logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT changseho logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis AT parkdongjun logisticorgandysfunctionsystemscorepredictstheprognosisofpatientswithalcoholicketoacidosis |