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Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Context: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders. Objective: The present study evaluated the effects of...

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Autores principales: Dey, Yadu Nandan, Sharma, Garima, Wanjari, Manish M., Kumar, Dharmendra, Lomash, Vinay, Jadhav, Ankush D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011945/
https://www.ncbi.nlm.nih.gov/pubmed/27600166
http://dx.doi.org/10.1080/13880209.2016.1226904
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author Dey, Yadu Nandan
Sharma, Garima
Wanjari, Manish M.
Kumar, Dharmendra
Lomash, Vinay
Jadhav, Ankush D.
author_facet Dey, Yadu Nandan
Sharma, Garima
Wanjari, Manish M.
Kumar, Dharmendra
Lomash, Vinay
Jadhav, Ankush D.
author_sort Dey, Yadu Nandan
collection PubMed
description Context: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders. Objective: The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats. Materials and methods: Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500 mg/kg) or standard drug, prednisolone (PRDS) (4 mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48 h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon. Results: APME or APAE pretreatment significantly (p < .05–.001) prevented AA-induced reduction in body weight and increase in colitis parameters viz. stool consistency, colon weight/length ratio and ulcer score, area and index. Extracts treatment attenuated (p < .001) increase in alkaline phosphatase and lactate dehydrogenase in serum and myeloperoxidase activity and cytokines in colon tissue due to AA administration. Extracts treatment prevented AA-induced elevation in lipid peroxidation and decline in activities of superoxide dismutase and catalase and reduced-glutathione content (p < .05–.001) along with histopathological alterations. PRDS also showed similar ameliorative effect on colitis. Discussion and conclusion: APME and APAE showed a preventive effect on UC, and ameliorated inflammation and oxidative damage in colon. The effects may be attributed to presence of phytochemicals, betulinic acid, β-sitosterol, and glucomannan. In conclusion, the tuber of Amorphophallus paeoniifolius exhibited an anticolitic effect through anti-inflammatory and antioxidant action.
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spelling pubmed-70119452020-02-24 Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats Dey, Yadu Nandan Sharma, Garima Wanjari, Manish M. Kumar, Dharmendra Lomash, Vinay Jadhav, Ankush D. Pharm Biol Research Article Context: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders. Objective: The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats. Materials and methods: Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500 mg/kg) or standard drug, prednisolone (PRDS) (4 mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48 h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon. Results: APME or APAE pretreatment significantly (p < .05–.001) prevented AA-induced reduction in body weight and increase in colitis parameters viz. stool consistency, colon weight/length ratio and ulcer score, area and index. Extracts treatment attenuated (p < .001) increase in alkaline phosphatase and lactate dehydrogenase in serum and myeloperoxidase activity and cytokines in colon tissue due to AA administration. Extracts treatment prevented AA-induced elevation in lipid peroxidation and decline in activities of superoxide dismutase and catalase and reduced-glutathione content (p < .05–.001) along with histopathological alterations. PRDS also showed similar ameliorative effect on colitis. Discussion and conclusion: APME and APAE showed a preventive effect on UC, and ameliorated inflammation and oxidative damage in colon. The effects may be attributed to presence of phytochemicals, betulinic acid, β-sitosterol, and glucomannan. In conclusion, the tuber of Amorphophallus paeoniifolius exhibited an anticolitic effect through anti-inflammatory and antioxidant action. Taylor & Francis 2016-09-07 /pmc/articles/PMC7011945/ /pubmed/27600166 http://dx.doi.org/10.1080/13880209.2016.1226904 Text en © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dey, Yadu Nandan
Sharma, Garima
Wanjari, Manish M.
Kumar, Dharmendra
Lomash, Vinay
Jadhav, Ankush D.
Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
title Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
title_full Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
title_fullStr Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
title_full_unstemmed Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
title_short Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
title_sort beneficial effect of amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011945/
https://www.ncbi.nlm.nih.gov/pubmed/27600166
http://dx.doi.org/10.1080/13880209.2016.1226904
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