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Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition mechanism of the bile acid cholate to hCA II was provided in 2014 by X-ray crystallography. Herein, we extend the inhibi...

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Detalles Bibliográficos
Autores principales:	Nocentini, Alessio, Bonardi, Alessandro, Gratteri, Paola, Cerra, Bruno, Gioiello, Antimo, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011995/ https://www.ncbi.nlm.nih.gov/pubmed/30221552 http://dx.doi.org/10.1080/14756366.2018.1512597

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