Novel four-disulfide insulin analog with high aggregation stability and potency

Although insulin was first purified and used therapeutically almost a century ago, there is still a need to improve therapeutic efficacy and patient convenience. A key challenge is the requirement for refrigeration to avoid inactivation of insulin by aggregation/fibrillation. Here, in an effort to m...

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Detalles Bibliográficos
Autores principales: Xiong, Xiaochun, Blakely, Alan, Karra, Prasoona, VandenBerg, Michael A., Ghabash, Gabrielle, Whitby, Frank, Zhang, Yi Wolf, Webber, Matthew J., Holland, William L., Hill, Christopher P., Chou, Danny Hung-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012051/
https://www.ncbi.nlm.nih.gov/pubmed/32110371
http://dx.doi.org/10.1039/c9sc04555d

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