Role of Melatonin in the Regulation of Pain

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-...

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Detalles Bibliográficos
Autores principales: Xie, Shanshan, Fan, Wenguo, He, Hongwen, Huang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012243/
https://www.ncbi.nlm.nih.gov/pubmed/32104055
http://dx.doi.org/10.2147/JPR.S228577
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author Xie, Shanshan
Fan, Wenguo
He, Hongwen
Huang, Fang
author_facet Xie, Shanshan
Fan, Wenguo
He, Hongwen
Huang, Fang
author_sort Xie, Shanshan
collection PubMed
description Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms.
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spelling pubmed-70122432020-02-26 Role of Melatonin in the Regulation of Pain Xie, Shanshan Fan, Wenguo He, Hongwen Huang, Fang J Pain Res Review Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms. Dove 2020-02-07 /pmc/articles/PMC7012243/ /pubmed/32104055 http://dx.doi.org/10.2147/JPR.S228577 Text en © 2020 Xie et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Xie, Shanshan
Fan, Wenguo
He, Hongwen
Huang, Fang
Role of Melatonin in the Regulation of Pain
title Role of Melatonin in the Regulation of Pain
title_full Role of Melatonin in the Regulation of Pain
title_fullStr Role of Melatonin in the Regulation of Pain
title_full_unstemmed Role of Melatonin in the Regulation of Pain
title_short Role of Melatonin in the Regulation of Pain
title_sort role of melatonin in the regulation of pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012243/
https://www.ncbi.nlm.nih.gov/pubmed/32104055
http://dx.doi.org/10.2147/JPR.S228577
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