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The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
PURPOSE: Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012266/ https://www.ncbi.nlm.nih.gov/pubmed/32082622 http://dx.doi.org/10.1155/2019/8391924 |
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author | Mamontov, Oleg V. Kozlenok, Andrey V. Kamshilin, Alexei A. Shlyakhto, Evgeny V. |
author_facet | Mamontov, Oleg V. Kozlenok, Andrey V. Kamshilin, Alexei A. Shlyakhto, Evgeny V. |
author_sort | Mamontov, Oleg V. |
collection | PubMed |
description | PURPOSE: Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up observation of 55 patients. METHODS: All patients were with target organ damage, and 27 of them had associated clinical conditions (ACC). Mean age of patients with and without ACC was 62.6 ± 4.2 and 51.9 ± 9.9 (mean ± SD) years, respectively. Follow-up was from 66 to 95 months. At entry, autonomic regulation was assessed by the tilt test, Valsalva maneuver, hand-grip test, and cold-stress vasoconstriction. Hemodynamic parameters were measured by continuous blood pressure monitoring, occlusion plethysmography, and electrocardiography. Re-examination of patients was carried out by questioning and physical and laboratory examination. RESULTS: We found that fatal outcomes were associated with a lower Valsalva index (1.34 ± 0.16 vs. 1.69 ± 0.37, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, CONCLUSIONS: This study shows that such autonomic regulation indices as Valsalva index, blood pressure dynamics in the tilt test, cold-stress vasomotor reactivity, and BPV are important for prognosis of hypertension course. |
format | Online Article Text |
id | pubmed-7012266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70122662020-02-20 The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study Mamontov, Oleg V. Kozlenok, Andrey V. Kamshilin, Alexei A. Shlyakhto, Evgeny V. Cardiol Res Pract Research Article PURPOSE: Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up observation of 55 patients. METHODS: All patients were with target organ damage, and 27 of them had associated clinical conditions (ACC). Mean age of patients with and without ACC was 62.6 ± 4.2 and 51.9 ± 9.9 (mean ± SD) years, respectively. Follow-up was from 66 to 95 months. At entry, autonomic regulation was assessed by the tilt test, Valsalva maneuver, hand-grip test, and cold-stress vasoconstriction. Hemodynamic parameters were measured by continuous blood pressure monitoring, occlusion plethysmography, and electrocardiography. Re-examination of patients was carried out by questioning and physical and laboratory examination. RESULTS: We found that fatal outcomes were associated with a lower Valsalva index (1.34 ± 0.16 vs. 1.69 ± 0.37, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, CONCLUSIONS: This study shows that such autonomic regulation indices as Valsalva index, blood pressure dynamics in the tilt test, cold-stress vasomotor reactivity, and BPV are important for prognosis of hypertension course. Hindawi 2019-12-30 /pmc/articles/PMC7012266/ /pubmed/32082622 http://dx.doi.org/10.1155/2019/8391924 Text en Copyright © 2019 Oleg V. Mamontov et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mamontov, Oleg V. Kozlenok, Andrey V. Kamshilin, Alexei A. Shlyakhto, Evgeny V. The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study |
title | The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study |
title_full | The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study |
title_fullStr | The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study |
title_full_unstemmed | The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study |
title_short | The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study |
title_sort | autonomic regulation of circulation and adverse events in hypertensive patients during follow-up study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012266/ https://www.ncbi.nlm.nih.gov/pubmed/32082622 http://dx.doi.org/10.1155/2019/8391924 |
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