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The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study

PURPOSE: Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up...

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Autores principales: Mamontov, Oleg V., Kozlenok, Andrey V., Kamshilin, Alexei A., Shlyakhto, Evgeny V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012266/
https://www.ncbi.nlm.nih.gov/pubmed/32082622
http://dx.doi.org/10.1155/2019/8391924
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author Mamontov, Oleg V.
Kozlenok, Andrey V.
Kamshilin, Alexei A.
Shlyakhto, Evgeny V.
author_facet Mamontov, Oleg V.
Kozlenok, Andrey V.
Kamshilin, Alexei A.
Shlyakhto, Evgeny V.
author_sort Mamontov, Oleg V.
collection PubMed
description PURPOSE: Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up observation of 55 patients. METHODS: All patients were with target organ damage, and 27 of them had associated clinical conditions (ACC). Mean age of patients with and without ACC was 62.6 ± 4.2 and 51.9 ± 9.9 (mean ± SD) years, respectively. Follow-up was from 66 to 95 months. At entry, autonomic regulation was assessed by the tilt test, Valsalva maneuver, hand-grip test, and cold-stress vasoconstriction. Hemodynamic parameters were measured by continuous blood pressure monitoring, occlusion plethysmography, and electrocardiography. Re-examination of patients was carried out by questioning and physical and laboratory examination. RESULTS: We found that fatal outcomes were associated with a lower Valsalva index (1.34 ± 0.16 vs. 1.69 ± 0.37, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, CONCLUSIONS: This study shows that such autonomic regulation indices as Valsalva index, blood pressure dynamics in the tilt test, cold-stress vasomotor reactivity, and BPV are important for prognosis of hypertension course.
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spelling pubmed-70122662020-02-20 The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study Mamontov, Oleg V. Kozlenok, Andrey V. Kamshilin, Alexei A. Shlyakhto, Evgeny V. Cardiol Res Pract Research Article PURPOSE: Comprehensive study of autonomic regulation assessed during follow-up could provide new detailed information about the risks stratification for hypertensive patients. Therefore, we investigated the associations of these indices with death, stroke, and revascularization during the follow-up observation of 55 patients. METHODS: All patients were with target organ damage, and 27 of them had associated clinical conditions (ACC). Mean age of patients with and without ACC was 62.6 ± 4.2 and 51.9 ± 9.9 (mean ± SD) years, respectively. Follow-up was from 66 to 95 months. At entry, autonomic regulation was assessed by the tilt test, Valsalva maneuver, hand-grip test, and cold-stress vasoconstriction. Hemodynamic parameters were measured by continuous blood pressure monitoring, occlusion plethysmography, and electrocardiography. Re-examination of patients was carried out by questioning and physical and laboratory examination. RESULTS: We found that fatal outcomes were associated with a lower Valsalva index (1.34 ± 0.16 vs. 1.69 ± 0.37, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, P < 0.05) and depressed cold vasoconstriction (0.20 ± 0.02 vs. 0.39 ± 0.16%, CONCLUSIONS: This study shows that such autonomic regulation indices as Valsalva index, blood pressure dynamics in the tilt test, cold-stress vasomotor reactivity, and BPV are important for prognosis of hypertension course. Hindawi 2019-12-30 /pmc/articles/PMC7012266/ /pubmed/32082622 http://dx.doi.org/10.1155/2019/8391924 Text en Copyright © 2019 Oleg V. Mamontov et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mamontov, Oleg V.
Kozlenok, Andrey V.
Kamshilin, Alexei A.
Shlyakhto, Evgeny V.
The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
title The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
title_full The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
title_fullStr The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
title_full_unstemmed The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
title_short The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study
title_sort autonomic regulation of circulation and adverse events in hypertensive patients during follow-up study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012266/
https://www.ncbi.nlm.nih.gov/pubmed/32082622
http://dx.doi.org/10.1155/2019/8391924
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