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Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma

Curcumin has been shown to have anticancer effects in a variety of tumors. However, there are fewer studies on the role of curcumin in endometrial carcinoma (EC). The purpose of this experiment was to examine the inhibitory effect of curcumin on endometrial carcinoma cells and ERK/c-Jun signaling pa...

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Autores principales: Zhang, Zhenxue, Yi, Pengfei, Tu, Changchun, Zhan, Jiejie, Jiang, Liping, Zhang, Fanglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012278/
https://www.ncbi.nlm.nih.gov/pubmed/32083122
http://dx.doi.org/10.1155/2019/8912961
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author Zhang, Zhenxue
Yi, Pengfei
Tu, Changchun
Zhan, Jiejie
Jiang, Liping
Zhang, Fanglin
author_facet Zhang, Zhenxue
Yi, Pengfei
Tu, Changchun
Zhan, Jiejie
Jiang, Liping
Zhang, Fanglin
author_sort Zhang, Zhenxue
collection PubMed
description Curcumin has been shown to have anticancer effects in a variety of tumors. However, there are fewer studies on the role of curcumin in endometrial carcinoma (EC). The purpose of this experiment was to examine the inhibitory effect of curcumin on endometrial carcinoma cells and ERK/c-Jun signaling pathway. We first predicted the mechanism of action of curcumin on endometrial carcinoma by network pharmacology. Then, we found that curcumin can decrease the cell viability of Ishikawa cells, inhibit the migration of cancer cells, induce apoptosis, and cause cell cycle arrest in the S phase. For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun. This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity.
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spelling pubmed-70122782020-02-20 Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma Zhang, Zhenxue Yi, Pengfei Tu, Changchun Zhan, Jiejie Jiang, Liping Zhang, Fanglin Biomed Res Int Research Article Curcumin has been shown to have anticancer effects in a variety of tumors. However, there are fewer studies on the role of curcumin in endometrial carcinoma (EC). The purpose of this experiment was to examine the inhibitory effect of curcumin on endometrial carcinoma cells and ERK/c-Jun signaling pathway. We first predicted the mechanism of action of curcumin on endometrial carcinoma by network pharmacology. Then, we found that curcumin can decrease the cell viability of Ishikawa cells, inhibit the migration of cancer cells, induce apoptosis, and cause cell cycle arrest in the S phase. For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun. This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity. Hindawi 2019-10-31 /pmc/articles/PMC7012278/ /pubmed/32083122 http://dx.doi.org/10.1155/2019/8912961 Text en Copyright © 2019 Zhenxue Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Zhenxue
Yi, Pengfei
Tu, Changchun
Zhan, Jiejie
Jiang, Liping
Zhang, Fanglin
Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
title Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
title_full Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
title_fullStr Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
title_full_unstemmed Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
title_short Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
title_sort curcumin inhibits erk/c-jun expressions and phosphorylation against endometrial carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012278/
https://www.ncbi.nlm.nih.gov/pubmed/32083122
http://dx.doi.org/10.1155/2019/8912961
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