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Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial

OBJECTIVE: To study silicone oil (SO) emulsification, anatomic and visual outcome after complicated retinal detachment surgery by pars plana vitrectomy (PPV) with intraocular SO tamponade, comparing between low and high viscosity SO. DESIGN: Randomized, double-blinded, controlled trial. PATIENTS AND...

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Autores principales: Ratanapakorn, Tanapat, Thongmee, Watcharaporn, Meethongkam, Kidakarn, Sinawat, Suthasinee, Sanguansak, Thuss, Bhoomibunchoo, Chavakij, Laovirojjanakul, Wipada, Yospaiboon, Yosanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012328/
https://www.ncbi.nlm.nih.gov/pubmed/32103882
http://dx.doi.org/10.2147/OPTH.S242804
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author Ratanapakorn, Tanapat
Thongmee, Watcharaporn
Meethongkam, Kidakarn
Sinawat, Suthasinee
Sanguansak, Thuss
Bhoomibunchoo, Chavakij
Laovirojjanakul, Wipada
Yospaiboon, Yosanan
author_facet Ratanapakorn, Tanapat
Thongmee, Watcharaporn
Meethongkam, Kidakarn
Sinawat, Suthasinee
Sanguansak, Thuss
Bhoomibunchoo, Chavakij
Laovirojjanakul, Wipada
Yospaiboon, Yosanan
author_sort Ratanapakorn, Tanapat
collection PubMed
description OBJECTIVE: To study silicone oil (SO) emulsification, anatomic and visual outcome after complicated retinal detachment surgery by pars plana vitrectomy (PPV) with intraocular SO tamponade, comparing between low and high viscosity SO. DESIGN: Randomized, double-blinded, controlled trial. PATIENTS AND METHODS: Patients with complicated retinal detachment who had been surgically treated by PPV and intraocular SO tamponade were randomly divided into low viscosity (Group 1) or high viscosity (Group 2). Main Outcome Measures were rate of silicone oil emulsification, anatomic retinal reattachment and visual outcome, assessed at 1,3,6,9 and 12 months. RESULTS: One hundred patients were divided into 50 patients in each group. The rate of silicone oil emulsification in Group 1 (63.64%) was higher than Group 2 (40%), but the difference was not statistically significant (p = 0.08). Rates of anatomic retinal reattachment were 88% in Group 1 and 90% in Group 2 (p = 0.76). For functional visual outcome, final best-corrected visual acuity (BCVA) at Month 12 compared with the baseline BCVA was improved vision 52% in Group 1 and 58% in Group 2 (p = 0.82). CONCLUSION: SO emulsification rate in low viscosity group is non-significantly higher than high viscosity group, but results in a comparable reattachment rate and final visual recovery. Emulsification in both groups is detected at as early as 1 month and mostly within 3 months. We recommend using either low or high viscosity SO in complicated retinal detachment surgery and removing it as early as possible to prevent the consequent serious complications. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02988583.
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spelling pubmed-70123282020-02-26 Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial Ratanapakorn, Tanapat Thongmee, Watcharaporn Meethongkam, Kidakarn Sinawat, Suthasinee Sanguansak, Thuss Bhoomibunchoo, Chavakij Laovirojjanakul, Wipada Yospaiboon, Yosanan Clin Ophthalmol Original Research OBJECTIVE: To study silicone oil (SO) emulsification, anatomic and visual outcome after complicated retinal detachment surgery by pars plana vitrectomy (PPV) with intraocular SO tamponade, comparing between low and high viscosity SO. DESIGN: Randomized, double-blinded, controlled trial. PATIENTS AND METHODS: Patients with complicated retinal detachment who had been surgically treated by PPV and intraocular SO tamponade were randomly divided into low viscosity (Group 1) or high viscosity (Group 2). Main Outcome Measures were rate of silicone oil emulsification, anatomic retinal reattachment and visual outcome, assessed at 1,3,6,9 and 12 months. RESULTS: One hundred patients were divided into 50 patients in each group. The rate of silicone oil emulsification in Group 1 (63.64%) was higher than Group 2 (40%), but the difference was not statistically significant (p = 0.08). Rates of anatomic retinal reattachment were 88% in Group 1 and 90% in Group 2 (p = 0.76). For functional visual outcome, final best-corrected visual acuity (BCVA) at Month 12 compared with the baseline BCVA was improved vision 52% in Group 1 and 58% in Group 2 (p = 0.82). CONCLUSION: SO emulsification rate in low viscosity group is non-significantly higher than high viscosity group, but results in a comparable reattachment rate and final visual recovery. Emulsification in both groups is detected at as early as 1 month and mostly within 3 months. We recommend using either low or high viscosity SO in complicated retinal detachment surgery and removing it as early as possible to prevent the consequent serious complications. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02988583. Dove 2020-02-07 /pmc/articles/PMC7012328/ /pubmed/32103882 http://dx.doi.org/10.2147/OPTH.S242804 Text en © 2020 Ratanapakorn et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ratanapakorn, Tanapat
Thongmee, Watcharaporn
Meethongkam, Kidakarn
Sinawat, Suthasinee
Sanguansak, Thuss
Bhoomibunchoo, Chavakij
Laovirojjanakul, Wipada
Yospaiboon, Yosanan
Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial
title Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial
title_full Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial
title_fullStr Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial
title_full_unstemmed Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial
title_short Emulsification of Different Viscosity Silicone Oil in Complicated Retinal Detachment Surgery: A Randomized Double-Blinded Clinical Trial
title_sort emulsification of different viscosity silicone oil in complicated retinal detachment surgery: a randomized double-blinded clinical trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012328/
https://www.ncbi.nlm.nih.gov/pubmed/32103882
http://dx.doi.org/10.2147/OPTH.S242804
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