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CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness
BACKGROUND AND AIM: Accumulating clinical and epidemiologic evidence indicates that nonalcoholic fatty liver disease (NAFLD) is not only associated with liver-related morbidity and mortality, but also with a greater risk of coronary heart disease (CHD). However, there is currently no diagnostic para...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health, Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012352/ https://www.ncbi.nlm.nih.gov/pubmed/31305280 http://dx.doi.org/10.1097/MCG.0000000000001238 |
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author | Song, Yan Dang, Ying Wang, Ping Tian, Gang Ruan, Litao |
author_facet | Song, Yan Dang, Ying Wang, Ping Tian, Gang Ruan, Litao |
author_sort | Song, Yan |
collection | PubMed |
description | BACKGROUND AND AIM: Accumulating clinical and epidemiologic evidence indicates that nonalcoholic fatty liver disease (NAFLD) is not only associated with liver-related morbidity and mortality, but also with a greater risk of coronary heart disease (CHD). However, there is currently no diagnostic parameter for NAFLD that has been determined to reliably indicate the presence of CHD as a co-morbidity. We evaluated the liver stiffness and visceral fat thickness of NAFLD patients ultrasonographically to explore the relationship between liver stiffness, visceral fat thickness, and CHD, aiming to find explore the relationship between the liver stiffness and CHD. METHODS: We enrolled 120 consecutive patients who had been initially diagnosed with CHD on the basis of their symptoms. All patients underwent coronary angiography or computed tomography angiography, and were classified into a CHD group and a non-CHD group on the basis of the results. All patients underwent liver ultrasonography, shear-wave elastography, and visceral fat thickness measurement. RESULTS: NAFLD and visceral fat thickness were significantly positively correlated with CHD and Gensini score (P<0.001). Multivariate regression showed that age, male, cholesterol, liver stiffness, and visceral fat thickness were determinants of CHD. Age, cholesterol, liver stiffness, and visceral fat thickness cut-off points for the prediction of CHD were above 50 years old [area under the curve (AUC): 0.678; sensitivity, 87%; specificity, 42.6%], >3.76 mmol/L (AUC: 0.687; sensitivity, 68.4%; specificity, 64.8%), >6.1 kPa (AUC: 0.798; sensitivity, 50%; specificity, 92.6%), and >7.41 cm (AUC: 0.694; sensitivity, 52.6%; specificity, 87%), respectively. Compared with the use of age, gender, and cholesterol (model 1), the addition of the liver stiffness cut-off to model 1 resulted in a stronger predictive value (P=0.005). CONCLUSIONS: High-grade NAFLD is more present in symptomatic CHD. The higher degree of liver stiffness in patients with NAFLD, the higher risk of CHD in these NAFLD patients. |
format | Online Article Text |
id | pubmed-7012352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health, Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-70123522020-02-19 CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness Song, Yan Dang, Ying Wang, Ping Tian, Gang Ruan, Litao J Clin Gastroenterol LIVER, PANCREAS & BILIARY TRACT: Original Articles BACKGROUND AND AIM: Accumulating clinical and epidemiologic evidence indicates that nonalcoholic fatty liver disease (NAFLD) is not only associated with liver-related morbidity and mortality, but also with a greater risk of coronary heart disease (CHD). However, there is currently no diagnostic parameter for NAFLD that has been determined to reliably indicate the presence of CHD as a co-morbidity. We evaluated the liver stiffness and visceral fat thickness of NAFLD patients ultrasonographically to explore the relationship between liver stiffness, visceral fat thickness, and CHD, aiming to find explore the relationship between the liver stiffness and CHD. METHODS: We enrolled 120 consecutive patients who had been initially diagnosed with CHD on the basis of their symptoms. All patients underwent coronary angiography or computed tomography angiography, and were classified into a CHD group and a non-CHD group on the basis of the results. All patients underwent liver ultrasonography, shear-wave elastography, and visceral fat thickness measurement. RESULTS: NAFLD and visceral fat thickness were significantly positively correlated with CHD and Gensini score (P<0.001). Multivariate regression showed that age, male, cholesterol, liver stiffness, and visceral fat thickness were determinants of CHD. Age, cholesterol, liver stiffness, and visceral fat thickness cut-off points for the prediction of CHD were above 50 years old [area under the curve (AUC): 0.678; sensitivity, 87%; specificity, 42.6%], >3.76 mmol/L (AUC: 0.687; sensitivity, 68.4%; specificity, 64.8%), >6.1 kPa (AUC: 0.798; sensitivity, 50%; specificity, 92.6%), and >7.41 cm (AUC: 0.694; sensitivity, 52.6%; specificity, 87%), respectively. Compared with the use of age, gender, and cholesterol (model 1), the addition of the liver stiffness cut-off to model 1 resulted in a stronger predictive value (P=0.005). CONCLUSIONS: High-grade NAFLD is more present in symptomatic CHD. The higher degree of liver stiffness in patients with NAFLD, the higher risk of CHD in these NAFLD patients. Wolters Kluwer Health, Inc 2020-03 2019-07-10 /pmc/articles/PMC7012352/ /pubmed/31305280 http://dx.doi.org/10.1097/MCG.0000000000001238 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | LIVER, PANCREAS & BILIARY TRACT: Original Articles Song, Yan Dang, Ying Wang, Ping Tian, Gang Ruan, Litao CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness |
title | CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness |
title_full | CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness |
title_fullStr | CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness |
title_full_unstemmed | CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness |
title_short | CHD is Associated With Higher Grades of NAFLD Predicted by Liver Stiffness |
title_sort | chd is associated with higher grades of nafld predicted by liver stiffness |
topic | LIVER, PANCREAS & BILIARY TRACT: Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012352/ https://www.ncbi.nlm.nih.gov/pubmed/31305280 http://dx.doi.org/10.1097/MCG.0000000000001238 |
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