Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias. RAF kinase inhibitor protein (RKIP) is a negative regulator of RAS-signaling. As RKIP loss ha...

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Detalles Bibliográficos
Autores principales: Caraffini, Veronica, Geiger, Olivia, Rosenberger, Angelika, Hatzl, Stefan, Perfler, Bianca, Berg, Johannes L., Lim, Clarice, Strobl, Herbert, Kashofer, Karl, Schauer, Silvia, Beham-Schmid, Christine, Hoefler, Gerald, Geissler, Klaus, Quehenberger, Franz, Kolch, Walter, Athineos, Dimitris, Blyth, Karen, Wölfler, Albert, Sill, Heinz, Zebisch, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012480/
https://www.ncbi.nlm.nih.gov/pubmed/31097632
http://dx.doi.org/10.3324/haematol.2018.209650

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