Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in multiple myeloma (MM). Hypersialylation can lead to increased immune evasion, drug resistance, tumor invasiveness, and...

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Detalles Bibliográficos
Autores principales: Natoni, Alessandro, Farrell, Mariah L., Harris, Sophie, Falank, Carolyne, Kirkham-McCarthy, Lucy, Macauley, Matthew S., Reagan, Michaela R., O’Dwyer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012485/
https://www.ncbi.nlm.nih.gov/pubmed/31101754
http://dx.doi.org/10.3324/haematol.2018.212266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012485/
https://www.ncbi.nlm.nih.gov/pubmed/31101754
http://dx.doi.org/10.3324/haematol.2018.212266

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