Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening

Chronic myeloid leukemia (CML) is caused by a balanced chromosomal translocation resulting in the formation of BCR-ABL1 fusion gene encoding a constitutively active BCR-ABL1 tyrosine kinase, which activates multiple signal transduction pathways leading to malignant transformation. Standard treatment...

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Detalles Bibliográficos
Autores principales: Outa, Amani Al, Abubaker, Dana, Bazarbachi, Ali, Sabban, Marwan El, Shirinian, Margret, Nasr, Rihab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012492/
https://www.ncbi.nlm.nih.gov/pubmed/31101753
http://dx.doi.org/10.3324/haematol.2019.219394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012492/
https://www.ncbi.nlm.nih.gov/pubmed/31101753
http://dx.doi.org/10.3324/haematol.2019.219394

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