High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

Recurrent gain-of-function mutations in the transcription factors STAT5A and much more in STAT5B were found in hematopoietic malignancies with the highest proportion in mature T- and natural killer-cell neoplasms (peripheral T-cell lymphoma, PTCL). No targeted therapy exists for these heterogeneous...

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Detalles Bibliográficos
Autores principales: Maurer, Barbara, Nivarthi, Harini, Wingelhofer, Bettina, Pham, Ha Thi Thanh, Schlederer, Michaela, Suske, Tobias, Grausenburger, Reinhard, Schiefer, Ana-Iris, Prchal-Murphy, Michaela, Chen, Doris, Winkler, Susanne, Merkel, Olaf, Kornauth, Christoph, Hofbauer, Maximilian, Hochgatterer, Birgit, Hoermann, Gregor, Hoelbl-Kovacic, Andrea, Prochazkova, Jana, Lobello, Cosimo, Cumaraswamy, Abbarna A., Latzka, Johanna, Kitzwögerer, Melitta, Chott, Andreas, Janikova, Andrea, Pospíšilova, Šárka, Loizou, Joanna I., Kubicek, Stefan, Valent, Peter, Kolbe, Thomas, Grebien, Florian, Kenner, Lukas, Gunning, Patrick T., Kralovics, Robert, Herling, Marco, Müller, Mathias, Rülicke, Thomas, Sexl, Veronika, Moriggl, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012494/
https://www.ncbi.nlm.nih.gov/pubmed/31123029
http://dx.doi.org/10.3324/haematol.2019.216986

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