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Body height in young adult men and risk of dementia later in adult life

This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board...

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Autores principales: Jørgensen, Terese Sara Høj, Okholm, Gunhild Tidemann, Christensen, Kaare, Sørensen, Thorkild IA, Osler, Merere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012597/
https://www.ncbi.nlm.nih.gov/pubmed/32041683
http://dx.doi.org/10.7554/eLife.51168
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author Jørgensen, Terese Sara Høj
Okholm, Gunhild Tidemann
Christensen, Kaare
Sørensen, Thorkild IA
Osler, Merere
author_facet Jørgensen, Terese Sara Høj
Okholm, Gunhild Tidemann
Christensen, Kaare
Sørensen, Thorkild IA
Osler, Merere
author_sort Jørgensen, Terese Sara Høj
collection PubMed
description This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates.
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spelling pubmed-70125972020-02-12 Body height in young adult men and risk of dementia later in adult life Jørgensen, Terese Sara Høj Okholm, Gunhild Tidemann Christensen, Kaare Sørensen, Thorkild IA Osler, Merere eLife Epidemiology and Global Health This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates. eLife Sciences Publications, Ltd 2020-02-11 /pmc/articles/PMC7012597/ /pubmed/32041683 http://dx.doi.org/10.7554/eLife.51168 Text en © 2020, Jørgensen et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Epidemiology and Global Health
Jørgensen, Terese Sara Høj
Okholm, Gunhild Tidemann
Christensen, Kaare
Sørensen, Thorkild IA
Osler, Merere
Body height in young adult men and risk of dementia later in adult life
title Body height in young adult men and risk of dementia later in adult life
title_full Body height in young adult men and risk of dementia later in adult life
title_fullStr Body height in young adult men and risk of dementia later in adult life
title_full_unstemmed Body height in young adult men and risk of dementia later in adult life
title_short Body height in young adult men and risk of dementia later in adult life
title_sort body height in young adult men and risk of dementia later in adult life
topic Epidemiology and Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012597/
https://www.ncbi.nlm.nih.gov/pubmed/32041683
http://dx.doi.org/10.7554/eLife.51168
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