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Body height in young adult men and risk of dementia later in adult life
This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012597/ https://www.ncbi.nlm.nih.gov/pubmed/32041683 http://dx.doi.org/10.7554/eLife.51168 |
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author | Jørgensen, Terese Sara Høj Okholm, Gunhild Tidemann Christensen, Kaare Sørensen, Thorkild IA Osler, Merere |
author_facet | Jørgensen, Terese Sara Høj Okholm, Gunhild Tidemann Christensen, Kaare Sørensen, Thorkild IA Osler, Merere |
author_sort | Jørgensen, Terese Sara Høj |
collection | PubMed |
description | This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates. |
format | Online Article Text |
id | pubmed-7012597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-70125972020-02-12 Body height in young adult men and risk of dementia later in adult life Jørgensen, Terese Sara Høj Okholm, Gunhild Tidemann Christensen, Kaare Sørensen, Thorkild IA Osler, Merere eLife Epidemiology and Global Health This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates. eLife Sciences Publications, Ltd 2020-02-11 /pmc/articles/PMC7012597/ /pubmed/32041683 http://dx.doi.org/10.7554/eLife.51168 Text en © 2020, Jørgensen et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Epidemiology and Global Health Jørgensen, Terese Sara Høj Okholm, Gunhild Tidemann Christensen, Kaare Sørensen, Thorkild IA Osler, Merere Body height in young adult men and risk of dementia later in adult life |
title | Body height in young adult men and risk of dementia later in adult life |
title_full | Body height in young adult men and risk of dementia later in adult life |
title_fullStr | Body height in young adult men and risk of dementia later in adult life |
title_full_unstemmed | Body height in young adult men and risk of dementia later in adult life |
title_short | Body height in young adult men and risk of dementia later in adult life |
title_sort | body height in young adult men and risk of dementia later in adult life |
topic | Epidemiology and Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012597/ https://www.ncbi.nlm.nih.gov/pubmed/32041683 http://dx.doi.org/10.7554/eLife.51168 |
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