Cargando…

Effect of the Recombinant Adenovirus-Mediated HIF-1 Alpha on the Expression of VEGF in the Hypoxic Brain Microvascular Endothelial Cells of Rats

OBJECTIVE: To investigate the effect of recombinant adenovirus-mediated HIF-1 alpha (HIF-1α) on the expression of vascular endothelial growth factor (VEGFA) and HIF-1α in hypoxic brain microvascular endothelial cells (BMEC) in rats. METHODS: Primary cultured rat BMEC in vitro were treated without or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Ming-Lu, Zou, Zhe-Hua, Tao, Tao, Li, Jun, Xu, Jian, Luo, Kai-Jian, Liu, Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012637/ https://www.ncbi.nlm.nih.gov/pubmed/32103959 http://dx.doi.org/10.2147/NDT.S238616

Ejemplares similares

Hypoxic Regulation of VEGF, HIF-1(alpha) in Coronary Collaterals Development
por: Sung, Ki Chul, et al.
Publicado: (2005)

Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis
por: Mao, Jing, et al.
Publicado: (2022)

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions
por: Dong, Xiao, et al.
Publicado: (2011)

Digoxin Downregulates NDRG1 and VEGF through the Inhibition of HIF-1α under Hypoxic Conditions in Human Lung Adenocarcinoma A549 Cells
por: Wei, Dong, et al.
Publicado: (2013)

IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells
por: Liu, Jie, et al.
Publicado: (2018)

Recombinant Adenovirus-Mediated HIF-lα Ameliorates Neurological Dysfunction by Improving Energy Metabolism in Ischemic Penumbra After Cerebral Ischemia-Reperfusion in Rats
por: Zhou, Wenmei, et al.
Publicado: (2023)

Antiapoptotic Effect of Gene Therapy with Recombinant Adenovirus Vector Containing Hypoxia-inducible Factor-1α after Cerebral Ischemia and Reperfusion in Rats
por: Yang, Ming-Lang, et al.
Publicado: (2017)

Endogenous reactive oxygen species and nitric oxide have opposite roles in regulating HIF-1alpha expression in hypoxic astrocytes
por: Chen, Qingquan, et al.
Publicado: (2021)

Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF-1α and VEGF expression
por: Dong, Dan, et al.
Publicado: (2021)

γ-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1α/VEGF pathways under hypoxic condition
por: Xiao, Heng, et al.
Publicado: (2014)

Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells
por: Silva, Juliete A. F., et al.
Publicado: (2021)

Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1α, HSP-70 and VEGF Pathways in Rat’s Kidneys Induced by Hypoxic Stress
por: Alshanwani, Aliah R., et al.
Publicado: (2020)

Antagonistic effects of endostatin-vascular endothelial growth inhibitor chimeric recombinant adenovirus on homocysteine-induced vascular endothelial cells injury in vitro and in vivo
por: Cui, Zhen-Tian, et al.
Publicado: (2016)

Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon
por: Branco-Price, Cristina, et al.
Publicado: (2013)

Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
por: Cao, Dan, et al.
Publicado: (2009)

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF
por: Cheng, Jiao, et al.
Publicado: (2019)

Knockdown of Nrf2 Inhibits the Angiogenesis of Rat Cardiac Micro-vascular Endothelial Cells under Hypoxic Conditions
por: Kuang, Lihong, et al.
Publicado: (2013)

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells
por: Harrison, Hannah, et al.
Publicado: (2018)

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells
por: Ourradi, Khadija, et al.
Publicado: (2017)

Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy
por: Watanabe, Maki, et al.
Publicado: (2021)

Relationship between the expression of CD133, HIF-1α, VEGF and the proliferation and apoptosis in hypoxic human prostate cancer cells
por: Liu, Lingyun, et al.
Publicado: (2017)

Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF
por: Wang, Lei, et al.
Publicado: (2023)

Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1α/VEGF Signaling Pathway
por: Tang, Zhi, et al.
Publicado: (2021)

Hypoxic Pretreatment of Adipose-Derived Stem Cells Accelerates Diabetic Wound Healing via circ-Gcap14 and HIF-1α/VEGF Mediated Angiopoiesis
por: Wang, Zhi, et al.
Publicado: (2021)

Thrombotic Alterations under Perinatal Hypoxic Conditions: HIF and Other Hypoxic Markers
por: Berna-Erro, Alejandro, et al.
Publicado: (2023)

Transcellular Targeting of Fiber- and Hexon-Modified Adenovirus Vectors across the Brain Microvascular Endothelial Cells In Vitro
por: Laakkonen, Johanna P., et al.
Publicado: (2012)

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells
por: Moszyńska, Adrianna, et al.
Publicado: (2020)

Molecular Characterization of EG-VEGF-mediated Angiogenesis: Differential Effects on Microvascular and Macrovascular Endothelial Cells
por: Brouillet, Sophie, et al.
Publicado: (2010)

KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells
por: Wang, Yinan, et al.
Publicado: (2015)

Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF
por: Lee, Sae-Won, et al.
Publicado: (2012)

STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway
por: Liu, Yang, et al.
Publicado: (2017)

HIF-1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia-reperfusion injury in a rat MCAO model
por: Li, Jun, et al.
Publicado: (2020)

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF
por: Schipani, Ernestina, et al.
Publicado: (2009)

ATP-binding cassette transporters in immortalised human brain microvascular endothelial cells in normal and hypoxic conditions
por: Lindner, Christian, et al.
Publicado: (2012)

The Relationship between HIF-2α and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee
por: Jian-lin, Zhou, et al.
Publicado: (2016)

Retraction: Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF
Publicado: (2020)

Effects of testosterone on the expression levels of AMH, VEGF and HIF-1α in mouse granulosa cells
por: Zhang, Ying, et al.
Publicado: (2016)

Protective effect of hypoxia inducible factor-1α gene therapy using recombinant adenovirus in cerebral ischaemia-reperfusion injuries in rats
por: Li, Ya-Qi, et al.
Publicado: (2020)

Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion
por: Zheng, Feihui, et al.
Publicado: (2016)

UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell–Induced Angiogenesis Through Suppressing HIF-1α/VEGF/IL-8 Intercellular Signaling
por: Lin, Wanfu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mh3469ckrfu945uk8be3gfdl5f