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The Role of Macrophages in Aortic Dissection

Aortic dissection (AD) is a fatal disease that accounts for a large proportion of aortic-related deaths and has an incidence of about 3–4 per 100,000 individuals every year. Recent studies have found that inflammation plays an important role in the development of AD, and that macrophages are the hub...

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Autores principales: Wang, Xinhao, Zhang, Hongpeng, Cao, Long, He, Yuan, Ma, Airong, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013038/
https://www.ncbi.nlm.nih.gov/pubmed/32116765
http://dx.doi.org/10.3389/fphys.2020.00054
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author Wang, Xinhao
Zhang, Hongpeng
Cao, Long
He, Yuan
Ma, Airong
Guo, Wei
author_facet Wang, Xinhao
Zhang, Hongpeng
Cao, Long
He, Yuan
Ma, Airong
Guo, Wei
author_sort Wang, Xinhao
collection PubMed
description Aortic dissection (AD) is a fatal disease that accounts for a large proportion of aortic-related deaths and has an incidence of about 3–4 per 100,000 individuals every year. Recent studies have found that inflammation plays an important role in the development of AD, and that macrophages are the hub of inflammation in the aortic wall. Aortic samples from AD patients reveal a large amount of macrophage infiltration. The sites of macrophage infiltration and activity vary throughout the different stages of AD, with involvement even in the tissue repair phase of AD. Angiotensin II has been shown to be an important factor in the stimulation of macrophage activity. Stimulated macrophages can secrete metalloproteinases, inflammatory factors and other substances to cause matrix destruction, smooth muscle cell apoptosis, neovascularization and more, all of which destroy the aortic wall structure. At the same time, there are a number of factors that regulate macrophages to reduce the formation of AD and induce the repair of torn aortic tissues. The aim of this review is to take a close look at the roles of macrophages throughout the course of AD disease.
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spelling pubmed-70130382020-02-28 The Role of Macrophages in Aortic Dissection Wang, Xinhao Zhang, Hongpeng Cao, Long He, Yuan Ma, Airong Guo, Wei Front Physiol Physiology Aortic dissection (AD) is a fatal disease that accounts for a large proportion of aortic-related deaths and has an incidence of about 3–4 per 100,000 individuals every year. Recent studies have found that inflammation plays an important role in the development of AD, and that macrophages are the hub of inflammation in the aortic wall. Aortic samples from AD patients reveal a large amount of macrophage infiltration. The sites of macrophage infiltration and activity vary throughout the different stages of AD, with involvement even in the tissue repair phase of AD. Angiotensin II has been shown to be an important factor in the stimulation of macrophage activity. Stimulated macrophages can secrete metalloproteinases, inflammatory factors and other substances to cause matrix destruction, smooth muscle cell apoptosis, neovascularization and more, all of which destroy the aortic wall structure. At the same time, there are a number of factors that regulate macrophages to reduce the formation of AD and induce the repair of torn aortic tissues. The aim of this review is to take a close look at the roles of macrophages throughout the course of AD disease. Frontiers Media S.A. 2020-02-05 /pmc/articles/PMC7013038/ /pubmed/32116765 http://dx.doi.org/10.3389/fphys.2020.00054 Text en Copyright © 2020 Wang, Zhang, Cao, He, Ma and Guo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Xinhao
Zhang, Hongpeng
Cao, Long
He, Yuan
Ma, Airong
Guo, Wei
The Role of Macrophages in Aortic Dissection
title The Role of Macrophages in Aortic Dissection
title_full The Role of Macrophages in Aortic Dissection
title_fullStr The Role of Macrophages in Aortic Dissection
title_full_unstemmed The Role of Macrophages in Aortic Dissection
title_short The Role of Macrophages in Aortic Dissection
title_sort role of macrophages in aortic dissection
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013038/
https://www.ncbi.nlm.nih.gov/pubmed/32116765
http://dx.doi.org/10.3389/fphys.2020.00054
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