Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma

To address the problem of poor asthma control due to drug resistance, an antisense oligonucleotide complementary to mmu-miR-145a-5p (antimiR-145) was tested in a house dust mite mouse model of mild/moderate asthma. miR-145 was targeted to reduce inflammation, regulate epithelial-mesenchymal transiti...

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Detalles Bibliográficos
Autores principales: Ramelli, Sabrina C., Comer, Brian S., McLendon, Jared M., Sandy, Lydia L., Ferretti, Andrew P., Barrington, Robert, Sparks, Jeff, Matar, Majed, Fewell, Jason, Gerthoffer, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013130/
https://www.ncbi.nlm.nih.gov/pubmed/32044723
http://dx.doi.org/10.1016/j.omtn.2019.12.033

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