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Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics

Breath-O™ Correct Ortho-K lenses are newly designed ortho-K lenses which are made from a silicon and fluoride containing methacrylate compound. This compound is said to be more flexible, durable and less likely to break compared to traditional Ortho-K lenses. The special design of this Ortho-K lens...

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Autores principales: Tse, Jimmy Sung-Hei, Lam, Thomas Chuen, Cheung, Jimmy Kai-Wai, Sze, Ying-Hon, Wong, Tsz-King, Chan, Henry Ho-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013139/
https://www.ncbi.nlm.nih.gov/pubmed/32071970
http://dx.doi.org/10.1016/j.dib.2020.105186
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author Tse, Jimmy Sung-Hei
Lam, Thomas Chuen
Cheung, Jimmy Kai-Wai
Sze, Ying-Hon
Wong, Tsz-King
Chan, Henry Ho-Lung
author_facet Tse, Jimmy Sung-Hei
Lam, Thomas Chuen
Cheung, Jimmy Kai-Wai
Sze, Ying-Hon
Wong, Tsz-King
Chan, Henry Ho-Lung
author_sort Tse, Jimmy Sung-Hei
collection PubMed
description Breath-O™ Correct Ortho-K lenses are newly designed ortho-K lenses which are made from a silicon and fluoride containing methacrylate compound. This compound is said to be more flexible, durable and less likely to break compared to traditional Ortho-K lenses. The special design of this Ortho-K lens can reshape the corneal profile to induce temporary myopic reduction while producing beneficial peripheral hyperopic defocus for myopia control. To evaluate the safety and ocular surface responses of overnight Ortho-K wear over 1 and 3 months using this new type of material, we evaluated the clinical parameters (corneal integrity, corneal biomechanics, corneal endothelial health, non-invasive keratographical break-up time) and profiled the change of global tear proteome on healthy young subjects using next generation proteomics (SWATH-MS). The acquired mass spectrometric data were processed and analyzed using a cloud based Oneomics™ bioinformatic platform. All raw data generated from Information-dependent acquisition (IDA) and SWATH acquisitions were accepted and published in the Peptide Atlas public repository for general release (http://www.peptideatlas.org/PASS/PASS01367).
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spelling pubmed-70131392020-02-18 Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics Tse, Jimmy Sung-Hei Lam, Thomas Chuen Cheung, Jimmy Kai-Wai Sze, Ying-Hon Wong, Tsz-King Chan, Henry Ho-Lung Data Brief Biochemistry, Genetics and Molecular Biology Breath-O™ Correct Ortho-K lenses are newly designed ortho-K lenses which are made from a silicon and fluoride containing methacrylate compound. This compound is said to be more flexible, durable and less likely to break compared to traditional Ortho-K lenses. The special design of this Ortho-K lens can reshape the corneal profile to induce temporary myopic reduction while producing beneficial peripheral hyperopic defocus for myopia control. To evaluate the safety and ocular surface responses of overnight Ortho-K wear over 1 and 3 months using this new type of material, we evaluated the clinical parameters (corneal integrity, corneal biomechanics, corneal endothelial health, non-invasive keratographical break-up time) and profiled the change of global tear proteome on healthy young subjects using next generation proteomics (SWATH-MS). The acquired mass spectrometric data were processed and analyzed using a cloud based Oneomics™ bioinformatic platform. All raw data generated from Information-dependent acquisition (IDA) and SWATH acquisitions were accepted and published in the Peptide Atlas public repository for general release (http://www.peptideatlas.org/PASS/PASS01367). Elsevier 2020-01-28 /pmc/articles/PMC7013139/ /pubmed/32071970 http://dx.doi.org/10.1016/j.dib.2020.105186 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Tse, Jimmy Sung-Hei
Lam, Thomas Chuen
Cheung, Jimmy Kai-Wai
Sze, Ying-Hon
Wong, Tsz-King
Chan, Henry Ho-Lung
Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics
title Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics
title_full Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics
title_fullStr Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics
title_full_unstemmed Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics
title_short Data on assessment of safety and tear proteome change in response to orthokeratology lens – Insight from integrating clinical data and next generation proteomics
title_sort data on assessment of safety and tear proteome change in response to orthokeratology lens – insight from integrating clinical data and next generation proteomics
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013139/
https://www.ncbi.nlm.nih.gov/pubmed/32071970
http://dx.doi.org/10.1016/j.dib.2020.105186
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