iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests

RAG2 severe combined immune deficiency (RAG2-SCID) is a lethal disorder caused by the absence of functional T and B cells due to a differentiation block. Here, we generated induced pluripotent stem cells (iPSCs) from a RAG2-SCID patient to study the nature of the T cell developmental blockade. We ob...

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Detalles Bibliográficos
Autores principales: Themeli, Maria, Chhatta, Amiet, Boersma, Hester, Prins, Henk Jan, Cordes, Martijn, de Wilt, Edwin, Farahani, Aïda Shahrabi, Vandekerckhove, Bart, van der Burg, Mirjam, Hoeben, Rob C., Staal, Frank J.T., Mikkers, Harald M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013232/
https://www.ncbi.nlm.nih.gov/pubmed/31956083
http://dx.doi.org/10.1016/j.stemcr.2019.12.010

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