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Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media
Inhibitors of Mek1/2 and Gsk3β, known as 2i, and, together with leukemia inhibitory factor, enhance the derivation of embryonic stem cells (ESCs) and promote ground-state pluripotency (2i/L-ESCs). However, recent reports show that prolonged Mek1/2 suppression impairs developmental potential of ESCs,...
Autores principales: | Wu, Baojiang, Li, Lin, Li, Bojiang, Gao, Junpeng, Chen, Yanglin, Wei, Mengyi, Yang, Zhiqing, Zhang, Baojing, Li, Shudong, Li, Kexin, Wang, Changshan, Surani, M. Azim, Li, Xihe, Tang, Fuchou, Bao, Siqin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013251/ https://www.ncbi.nlm.nih.gov/pubmed/32032551 http://dx.doi.org/10.1016/j.stemcr.2020.01.004 |
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