Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)

PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Combining Hsp90 inhibitors to enhance endoplasmic reticulum stress with mTOR inhibition results in dramatic MPNST shrinkage in a genetically engineered MPNST mouse model. Ganetespib is an injectable poten...

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Detalles Bibliográficos
Autores principales: Kim, AeRang, Lu, Yao, Okuno, Scott H., Reinke, Denise, Maertens, Ophélia, Perentesis, John, Basu, Mitali, Wolters, Pamela L., De Raedt, Thomas, Chawla, Sant, Chugh, Rashmi, Van Tine, Brian A., O'Sullivan, Geraldine, Chen, Alice, Cichowski, Karen, Widemann, Brigitte C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013290/
https://www.ncbi.nlm.nih.gov/pubmed/32089640
http://dx.doi.org/10.1155/2020/5784876

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