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Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength

Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves’ ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects...

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Autores principales: Schwiebert, Christian, Kühnen, Peter, Becker, Niels-Peter, Welsink, Tim, Keller, Theresa, Minich, Waldemar B., Wiegand, Susanna, Schomburg, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013472/
https://www.ncbi.nlm.nih.gov/pubmed/31940750
http://dx.doi.org/10.3390/ijms21020463
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author Schwiebert, Christian
Kühnen, Peter
Becker, Niels-Peter
Welsink, Tim
Keller, Theresa
Minich, Waldemar B.
Wiegand, Susanna
Schomburg, Lutz
author_facet Schwiebert, Christian
Kühnen, Peter
Becker, Niels-Peter
Welsink, Tim
Keller, Theresa
Minich, Waldemar B.
Wiegand, Susanna
Schomburg, Lutz
author_sort Schwiebert, Christian
collection PubMed
description Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves’ ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects (n = 143) were collected during a lifestyle intervention study. Anthropometric parameters, along with leptin, IGF1 and IGF1R-aAb concentrations, were analyzed, and the subjects were categorized into positive or negative for IGF1R-aAb. Eleven out of 143 subjects (7.7%) were positive for IGF1R-aAb. Identified IGF1R-aAb were molecularly characterized and showed antagonistic activity in vitro impairing IGF1-mediated IGF1R activation. Mean body weight, height or age were similar between IGF1R-aAb-positive and -negative subjects, but IGF1 concentrations differed. Jumping ability, as well as right and left handgrip strengths, were lower in the IGF1R-aAb-positive as compared to the IGF1R-aAb-negative subjects. We conclude that natural IGF1R-aAb are detectable in apparently healthy subjects and are capable of antagonizing IGF1-dependent IGF1R activation. Moreover, the presence of IGF1R-aAb is associated with poor physical strength. Although the causality of this association is unclear, the data imply a potential influence of IGF1R autoimmunity on muscle development.
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spelling pubmed-70134722020-03-09 Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength Schwiebert, Christian Kühnen, Peter Becker, Niels-Peter Welsink, Tim Keller, Theresa Minich, Waldemar B. Wiegand, Susanna Schomburg, Lutz Int J Mol Sci Article Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves’ ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects (n = 143) were collected during a lifestyle intervention study. Anthropometric parameters, along with leptin, IGF1 and IGF1R-aAb concentrations, were analyzed, and the subjects were categorized into positive or negative for IGF1R-aAb. Eleven out of 143 subjects (7.7%) were positive for IGF1R-aAb. Identified IGF1R-aAb were molecularly characterized and showed antagonistic activity in vitro impairing IGF1-mediated IGF1R activation. Mean body weight, height or age were similar between IGF1R-aAb-positive and -negative subjects, but IGF1 concentrations differed. Jumping ability, as well as right and left handgrip strengths, were lower in the IGF1R-aAb-positive as compared to the IGF1R-aAb-negative subjects. We conclude that natural IGF1R-aAb are detectable in apparently healthy subjects and are capable of antagonizing IGF1-dependent IGF1R activation. Moreover, the presence of IGF1R-aAb is associated with poor physical strength. Although the causality of this association is unclear, the data imply a potential influence of IGF1R autoimmunity on muscle development. MDPI 2020-01-11 /pmc/articles/PMC7013472/ /pubmed/31940750 http://dx.doi.org/10.3390/ijms21020463 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schwiebert, Christian
Kühnen, Peter
Becker, Niels-Peter
Welsink, Tim
Keller, Theresa
Minich, Waldemar B.
Wiegand, Susanna
Schomburg, Lutz
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
title Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
title_full Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
title_fullStr Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
title_full_unstemmed Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
title_short Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
title_sort antagonistic autoantibodies to insulin-like growth factor-1 receptor associate with poor physical strength
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013472/
https://www.ncbi.nlm.nih.gov/pubmed/31940750
http://dx.doi.org/10.3390/ijms21020463
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