GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo

Aldosterone is produced by adrenocortical zona glomerulosa (AZG) cells in response to angiotensin II (AngII) acting through its type I receptors (AT(1)Rs). AT(1)R is a G protein-coupled receptor (GPCR) that induces aldosterone via both G proteins and the adapter protein βarrestin1, which binds the r...

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Detalles Bibliográficos
Autores principales: Pollard, Celina M., Ghandour, Jennifer, Cora, Natalie, Perez, Arianna, Parker, Barbara M., Desimine, Victoria L., Wertz, Shelby L., Pereyra, Janelle M., Ferraino, Krysten E., Patel, Jainika J., Lymperopoulos, Anastasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013621/
https://www.ncbi.nlm.nih.gov/pubmed/31963151
http://dx.doi.org/10.3390/ijms21020574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013621/
https://www.ncbi.nlm.nih.gov/pubmed/31963151
http://dx.doi.org/10.3390/ijms21020574

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