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Genetically Engineered Pigs to Study Cancer
Recent decades have seen groundbreaking advances in cancer research. Genetically engineered animal models, mainly in mice, have contributed to a better understanding of the underlying mechanisms involved in cancer. However, mice are not ideal for translating basic research into studies closer to the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013672/ https://www.ncbi.nlm.nih.gov/pubmed/31940967 http://dx.doi.org/10.3390/ijms21020488 |
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author | Kalla, Daniela Kind, Alexander Schnieke, Angelika |
author_facet | Kalla, Daniela Kind, Alexander Schnieke, Angelika |
author_sort | Kalla, Daniela |
collection | PubMed |
description | Recent decades have seen groundbreaking advances in cancer research. Genetically engineered animal models, mainly in mice, have contributed to a better understanding of the underlying mechanisms involved in cancer. However, mice are not ideal for translating basic research into studies closer to the clinic. There is a need for complementary information provided by non-rodent species. Pigs are well suited for translational biomedical research as they share many similarities with humans such as body and organ size, aspects of anatomy, physiology and pathophysiology and can provide valuable means of developing and testing novel diagnostic and therapeutic procedures. Porcine oncology is a new field, but it is clear that replication of key oncogenic mutation in pigs can usefully mimic several human cancers. This review briefly outlines the technology used to generate genetically modified pigs, provides an overview of existing cancer models, their applications and how the field may develop in the near future. |
format | Online Article Text |
id | pubmed-7013672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70136722020-03-09 Genetically Engineered Pigs to Study Cancer Kalla, Daniela Kind, Alexander Schnieke, Angelika Int J Mol Sci Review Recent decades have seen groundbreaking advances in cancer research. Genetically engineered animal models, mainly in mice, have contributed to a better understanding of the underlying mechanisms involved in cancer. However, mice are not ideal for translating basic research into studies closer to the clinic. There is a need for complementary information provided by non-rodent species. Pigs are well suited for translational biomedical research as they share many similarities with humans such as body and organ size, aspects of anatomy, physiology and pathophysiology and can provide valuable means of developing and testing novel diagnostic and therapeutic procedures. Porcine oncology is a new field, but it is clear that replication of key oncogenic mutation in pigs can usefully mimic several human cancers. This review briefly outlines the technology used to generate genetically modified pigs, provides an overview of existing cancer models, their applications and how the field may develop in the near future. MDPI 2020-01-13 /pmc/articles/PMC7013672/ /pubmed/31940967 http://dx.doi.org/10.3390/ijms21020488 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kalla, Daniela Kind, Alexander Schnieke, Angelika Genetically Engineered Pigs to Study Cancer |
title | Genetically Engineered Pigs to Study Cancer |
title_full | Genetically Engineered Pigs to Study Cancer |
title_fullStr | Genetically Engineered Pigs to Study Cancer |
title_full_unstemmed | Genetically Engineered Pigs to Study Cancer |
title_short | Genetically Engineered Pigs to Study Cancer |
title_sort | genetically engineered pigs to study cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013672/ https://www.ncbi.nlm.nih.gov/pubmed/31940967 http://dx.doi.org/10.3390/ijms21020488 |
work_keys_str_mv | AT kalladaniela geneticallyengineeredpigstostudycancer AT kindalexander geneticallyengineeredpigstostudycancer AT schniekeangelika geneticallyengineeredpigstostudycancer |