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Genetically Engineered Pigs to Study Cancer

Recent decades have seen groundbreaking advances in cancer research. Genetically engineered animal models, mainly in mice, have contributed to a better understanding of the underlying mechanisms involved in cancer. However, mice are not ideal for translating basic research into studies closer to the...

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Detalles Bibliográficos
Autores principales: Kalla, Daniela, Kind, Alexander, Schnieke, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013672/
https://www.ncbi.nlm.nih.gov/pubmed/31940967
http://dx.doi.org/10.3390/ijms21020488
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author Kalla, Daniela
Kind, Alexander
Schnieke, Angelika
author_facet Kalla, Daniela
Kind, Alexander
Schnieke, Angelika
author_sort Kalla, Daniela
collection PubMed
description Recent decades have seen groundbreaking advances in cancer research. Genetically engineered animal models, mainly in mice, have contributed to a better understanding of the underlying mechanisms involved in cancer. However, mice are not ideal for translating basic research into studies closer to the clinic. There is a need for complementary information provided by non-rodent species. Pigs are well suited for translational biomedical research as they share many similarities with humans such as body and organ size, aspects of anatomy, physiology and pathophysiology and can provide valuable means of developing and testing novel diagnostic and therapeutic procedures. Porcine oncology is a new field, but it is clear that replication of key oncogenic mutation in pigs can usefully mimic several human cancers. This review briefly outlines the technology used to generate genetically modified pigs, provides an overview of existing cancer models, their applications and how the field may develop in the near future.
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spelling pubmed-70136722020-03-09 Genetically Engineered Pigs to Study Cancer Kalla, Daniela Kind, Alexander Schnieke, Angelika Int J Mol Sci Review Recent decades have seen groundbreaking advances in cancer research. Genetically engineered animal models, mainly in mice, have contributed to a better understanding of the underlying mechanisms involved in cancer. However, mice are not ideal for translating basic research into studies closer to the clinic. There is a need for complementary information provided by non-rodent species. Pigs are well suited for translational biomedical research as they share many similarities with humans such as body and organ size, aspects of anatomy, physiology and pathophysiology and can provide valuable means of developing and testing novel diagnostic and therapeutic procedures. Porcine oncology is a new field, but it is clear that replication of key oncogenic mutation in pigs can usefully mimic several human cancers. This review briefly outlines the technology used to generate genetically modified pigs, provides an overview of existing cancer models, their applications and how the field may develop in the near future. MDPI 2020-01-13 /pmc/articles/PMC7013672/ /pubmed/31940967 http://dx.doi.org/10.3390/ijms21020488 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kalla, Daniela
Kind, Alexander
Schnieke, Angelika
Genetically Engineered Pigs to Study Cancer
title Genetically Engineered Pigs to Study Cancer
title_full Genetically Engineered Pigs to Study Cancer
title_fullStr Genetically Engineered Pigs to Study Cancer
title_full_unstemmed Genetically Engineered Pigs to Study Cancer
title_short Genetically Engineered Pigs to Study Cancer
title_sort genetically engineered pigs to study cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013672/
https://www.ncbi.nlm.nih.gov/pubmed/31940967
http://dx.doi.org/10.3390/ijms21020488
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