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Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia

Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital...

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Autores principales: Suraya, Anna, Nowak, Dennis, Sulistomo, Astrid Widajati, Ghanie Icksan, Aziza, Syahruddin, Elisna, Berger, Ursula, Bose-O’Reilly, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013975/
https://www.ncbi.nlm.nih.gov/pubmed/31963324
http://dx.doi.org/10.3390/ijerph17020591
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author Suraya, Anna
Nowak, Dennis
Sulistomo, Astrid Widajati
Ghanie Icksan, Aziza
Syahruddin, Elisna
Berger, Ursula
Bose-O’Reilly, Stephan
author_facet Suraya, Anna
Nowak, Dennis
Sulistomo, Astrid Widajati
Ghanie Icksan, Aziza
Syahruddin, Elisna
Berger, Ursula
Bose-O’Reilly, Stephan
author_sort Suraya, Anna
collection PubMed
description Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards.
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spelling pubmed-70139752020-03-09 Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia Suraya, Anna Nowak, Dennis Sulistomo, Astrid Widajati Ghanie Icksan, Aziza Syahruddin, Elisna Berger, Ursula Bose-O’Reilly, Stephan Int J Environ Res Public Health Article Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards. MDPI 2020-01-16 2020-01 /pmc/articles/PMC7013975/ /pubmed/31963324 http://dx.doi.org/10.3390/ijerph17020591 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suraya, Anna
Nowak, Dennis
Sulistomo, Astrid Widajati
Ghanie Icksan, Aziza
Syahruddin, Elisna
Berger, Ursula
Bose-O’Reilly, Stephan
Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
title Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
title_full Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
title_fullStr Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
title_full_unstemmed Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
title_short Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
title_sort asbestos-related lung cancer: a hospital-based case-control study in indonesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013975/
https://www.ncbi.nlm.nih.gov/pubmed/31963324
http://dx.doi.org/10.3390/ijerph17020591
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