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Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia
Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013975/ https://www.ncbi.nlm.nih.gov/pubmed/31963324 http://dx.doi.org/10.3390/ijerph17020591 |
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author | Suraya, Anna Nowak, Dennis Sulistomo, Astrid Widajati Ghanie Icksan, Aziza Syahruddin, Elisna Berger, Ursula Bose-O’Reilly, Stephan |
author_facet | Suraya, Anna Nowak, Dennis Sulistomo, Astrid Widajati Ghanie Icksan, Aziza Syahruddin, Elisna Berger, Ursula Bose-O’Reilly, Stephan |
author_sort | Suraya, Anna |
collection | PubMed |
description | Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards. |
format | Online Article Text |
id | pubmed-7013975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70139752020-03-09 Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia Suraya, Anna Nowak, Dennis Sulistomo, Astrid Widajati Ghanie Icksan, Aziza Syahruddin, Elisna Berger, Ursula Bose-O’Reilly, Stephan Int J Environ Res Public Health Article Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards. MDPI 2020-01-16 2020-01 /pmc/articles/PMC7013975/ /pubmed/31963324 http://dx.doi.org/10.3390/ijerph17020591 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suraya, Anna Nowak, Dennis Sulistomo, Astrid Widajati Ghanie Icksan, Aziza Syahruddin, Elisna Berger, Ursula Bose-O’Reilly, Stephan Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia |
title | Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia |
title_full | Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia |
title_fullStr | Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia |
title_full_unstemmed | Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia |
title_short | Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia |
title_sort | asbestos-related lung cancer: a hospital-based case-control study in indonesia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013975/ https://www.ncbi.nlm.nih.gov/pubmed/31963324 http://dx.doi.org/10.3390/ijerph17020591 |
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