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Immunological Memory of Psoriatic Lesions
The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014148/ https://www.ncbi.nlm.nih.gov/pubmed/31963581 http://dx.doi.org/10.3390/ijms21020625 |
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author | Owczarczyk-Saczonek, Agnieszka Krajewska-Włodarczyk, Magdalena Kasprowicz-Furmańczyk, Marta Placek, Waldemar |
author_facet | Owczarczyk-Saczonek, Agnieszka Krajewska-Włodarczyk, Magdalena Kasprowicz-Furmańczyk, Marta Placek, Waldemar |
author_sort | Owczarczyk-Saczonek, Agnieszka |
collection | PubMed |
description | The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They are originally responsible for protection against viral and bacterial infections in non-lymphatic tissues. In psoriatic inflammation, they are characterized by heterogeneity depending on their origin. CD8+ T cells TRM are abundantly present in psoriatic epidermis, while CD4+ TRM preferentially populate the dermis. In psoriasis, epidermal CD8+ TRM cells express CLA, CCR6, CD103 and IL-23R antigen and produce IL-17A during ex vivo stimulation. However, CD4+ CD103+ TRM can also colonize the epidermis and produce IL-22 during stimulation. Besides T cells, Th22 and epidermal DCs proved that epidermal cells in healed skin were still present and functioning after several years of disease remission. It explains the clinical phenomenon of the tendency of psoriatic lesions to relapse in the same location and it allows to develop new therapeutic strategies in the future. |
format | Online Article Text |
id | pubmed-7014148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70141482020-03-09 Immunological Memory of Psoriatic Lesions Owczarczyk-Saczonek, Agnieszka Krajewska-Włodarczyk, Magdalena Kasprowicz-Furmańczyk, Marta Placek, Waldemar Int J Mol Sci Review The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They are originally responsible for protection against viral and bacterial infections in non-lymphatic tissues. In psoriatic inflammation, they are characterized by heterogeneity depending on their origin. CD8+ T cells TRM are abundantly present in psoriatic epidermis, while CD4+ TRM preferentially populate the dermis. In psoriasis, epidermal CD8+ TRM cells express CLA, CCR6, CD103 and IL-23R antigen and produce IL-17A during ex vivo stimulation. However, CD4+ CD103+ TRM can also colonize the epidermis and produce IL-22 during stimulation. Besides T cells, Th22 and epidermal DCs proved that epidermal cells in healed skin were still present and functioning after several years of disease remission. It explains the clinical phenomenon of the tendency of psoriatic lesions to relapse in the same location and it allows to develop new therapeutic strategies in the future. MDPI 2020-01-17 /pmc/articles/PMC7014148/ /pubmed/31963581 http://dx.doi.org/10.3390/ijms21020625 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Owczarczyk-Saczonek, Agnieszka Krajewska-Włodarczyk, Magdalena Kasprowicz-Furmańczyk, Marta Placek, Waldemar Immunological Memory of Psoriatic Lesions |
title | Immunological Memory of Psoriatic Lesions |
title_full | Immunological Memory of Psoriatic Lesions |
title_fullStr | Immunological Memory of Psoriatic Lesions |
title_full_unstemmed | Immunological Memory of Psoriatic Lesions |
title_short | Immunological Memory of Psoriatic Lesions |
title_sort | immunological memory of psoriatic lesions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014148/ https://www.ncbi.nlm.nih.gov/pubmed/31963581 http://dx.doi.org/10.3390/ijms21020625 |
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