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Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells

The corneal surface is an essential organ necessary for vision, and its clarity must be maintained. The corneal epithelium is renewed by limbal stem cells, located in the limbus and in palisades of Vogt. Palisades of Vogt maintain the clearness of the corneal epithelium by blocking the growth of con...

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Autores principales: Oliva, Joan, Bardag-Gorce, Fawzia, Niihara, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014181/
https://www.ncbi.nlm.nih.gov/pubmed/31936462
http://dx.doi.org/10.3390/ijms21020411
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author Oliva, Joan
Bardag-Gorce, Fawzia
Niihara, Yutaka
author_facet Oliva, Joan
Bardag-Gorce, Fawzia
Niihara, Yutaka
author_sort Oliva, Joan
collection PubMed
description The corneal surface is an essential organ necessary for vision, and its clarity must be maintained. The corneal epithelium is renewed by limbal stem cells, located in the limbus and in palisades of Vogt. Palisades of Vogt maintain the clearness of the corneal epithelium by blocking the growth of conjunctival epithelium and the invasion of blood vessels over the cornea. The limbal region can be damaged by chemical burns, physical damage (e.g., by contact lenses), congenital disease, chronic inflammation, or limbal surgeries. The degree of limbus damage is associated with the degree of limbal stem cells deficiency (partial or total). For a long time, the only treatment to restore vision was grafting part of the healthy cornea from the other eye of the patient or by transplanting a cornea from cadavers. The regenerative medicine and stem cell therapies have been applied to restore normal vision using different methodologies. The source of stem cells varies from embryonic stem cells, mesenchymal stem cells, to induced pluripotent stem cells. This review focuses on the use of oral mucosa epithelial stem cells and their use in engineering cell sheets to treat limbal stem cell deficient patients.
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spelling pubmed-70141812020-03-09 Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells Oliva, Joan Bardag-Gorce, Fawzia Niihara, Yutaka Int J Mol Sci Review The corneal surface is an essential organ necessary for vision, and its clarity must be maintained. The corneal epithelium is renewed by limbal stem cells, located in the limbus and in palisades of Vogt. Palisades of Vogt maintain the clearness of the corneal epithelium by blocking the growth of conjunctival epithelium and the invasion of blood vessels over the cornea. The limbal region can be damaged by chemical burns, physical damage (e.g., by contact lenses), congenital disease, chronic inflammation, or limbal surgeries. The degree of limbus damage is associated with the degree of limbal stem cells deficiency (partial or total). For a long time, the only treatment to restore vision was grafting part of the healthy cornea from the other eye of the patient or by transplanting a cornea from cadavers. The regenerative medicine and stem cell therapies have been applied to restore normal vision using different methodologies. The source of stem cells varies from embryonic stem cells, mesenchymal stem cells, to induced pluripotent stem cells. This review focuses on the use of oral mucosa epithelial stem cells and their use in engineering cell sheets to treat limbal stem cell deficient patients. MDPI 2020-01-09 /pmc/articles/PMC7014181/ /pubmed/31936462 http://dx.doi.org/10.3390/ijms21020411 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliva, Joan
Bardag-Gorce, Fawzia
Niihara, Yutaka
Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells
title Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells
title_full Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells
title_fullStr Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells
title_full_unstemmed Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells
title_short Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells
title_sort clinical trials of limbal stem cell deficiency treated with oral mucosal epithelial cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014181/
https://www.ncbi.nlm.nih.gov/pubmed/31936462
http://dx.doi.org/10.3390/ijms21020411
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