Cargando…

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to auto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borrás, Consuelo, Mas-Bargues, Cristina, Román-Domínguez, Aurora, Sanz-Ros, Jorge, Gimeno-Mallench, Lucia, Inglés, Marta, Gambini, Juan, Viña, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014191/ https://www.ncbi.nlm.nih.gov/pubmed/31936510 http://dx.doi.org/10.3390/ijms21020418

Ejemplares similares

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation
por: Mas-Bargues, Cristina, et al.
Publicado: (2020)

Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine
por: Mas-Bargues, Cristina, et al.
Publicado: (2019)

Bcl-xL as a Modulator of Senescence and Aging
por: Mas-Bargues, Cristina, et al.
Publicado: (2021)

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging
por: Borras, Consuelo, et al.
Publicado: (2016)

Relationship between Diet, Microbiota, and Healthy Aging
por: Sanchez-Morate, Elisa, et al.
Publicado: (2020)

Role of p16(INK4a) and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
por: Mas-Bargues, Cristina, et al.
Publicado: (2017)

Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction
por: Stromsnes, K., et al.
Publicado: (2020)

Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans
por: Gambini, J., et al.
Publicado: (2015)

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster
por: Gambini, Juan, et al.
Publicado: (2021)

Centenarians, but not octogenarians, up-regulate the expression of microRNAs
por: Serna, Eva, et al.
Publicado: (2012)

CORRIGENDUM: Centenarians, but not octogenarians, up-regulate the expression of microRNAs
por: Serna, Eva, et al.
Publicado: (2013)

Estrogen Replacement Therapy Induces Antioxidant and Longevity-Related Genes in Women after Medically Induced Menopause
por: Borrás, C., et al.
Publicado: (2021)

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice
por: Sanz-Ros, Jorge, et al.
Publicado: (2022)

Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress
por: Díaz, Ana, et al.
Publicado: (2019)

Activation of p38, p21, and NRF-2 Mediates Decreased Proliferation of Human Dental Pulp Stem Cells Cultured under 21% O(2)
por: El Alami, Marya, et al.
Publicado: (2014)

Recent Approaches to Determine Static and Dynamic Redox State-Related Parameters
por: Mas-Bargues, Cristina, et al.
Publicado: (2022)

The Role of Extracellular Vesicles in Aging and Disease
por: Borrás, Consuelo, et al.
Publicado: (2023)

Bcl-xL in neuroprotection and plasticity
por: Jonas, Elizabeth A., et al.
Publicado: (2014)

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma
por: Yoshimine, S, et al.
Publicado: (2013)

Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases
por: Sanz-Ros, Jorge, et al.
Publicado: (2022)

The Double-Edged Role of Extracellular Vesicles in the Hallmarks of Aging
por: Romero-García, Nekane, et al.
Publicado: (2023)

Extracellular Vesicles as Therapeutic Resources in the Clinical Environment
por: Sanz-Ros, Jorge, et al.
Publicado: (2023)

The Potential Use of Mitochondrial Extracellular Vesicles as Biomarkers or Therapeutical Tools
por: Sanz-Ros, Jorge, et al.
Publicado: (2023)

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans
por: Stromsnes, Kristine, et al.
Publicado: (2021)

Nutritional Regulators of Bcl-xL in the Brain
por: Park, Han-A, et al.
Publicado: (2018)

Targeting BCL-XL in fibrolamellar hepatocellular carcinoma
por: Shebl, Bassem, et al.
Publicado: (2022)

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
por: Yosef, Reut, et al.
Publicado: (2016)

Bcl-XL but Not Bcl-2 Is a Potential Target in Medulloblastoma Therapy
por: Westhoff, Mike-Andrew, et al.
Publicado: (2022)

Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage
por: Seng, NS, et al.
Publicado: (2016)

Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?
por: Romero-García, Nekane, et al.
Publicado: (2023)

The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification
por: Mas-Bargues, Cristina, et al.
Publicado: (2022)

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
por: He, Yonghan, et al.
Publicado: (2020)

Bcl-XL and Bcl-2 repress a common pathway of cell death
Publicado: (1995)

Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
por: Adams, Clare M., et al.
Publicado: (2019)

PTEN Mediates the Antioxidant Effect of Resveratrol at Nutritionally Relevant Concentrations
por: Inglés, Marta, et al.
Publicado: (2014)

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
por: Billen, Lieven P, et al.
Publicado: (2008)

Bcl-xL: A Focus on Melanoma Pathobiology
por: Lucianò, Anna Maria, et al.
Publicado: (2021)

Involvement of Bcl-xL in Neuronal Function and Development
por: Bas, Julie, et al.
Publicado: (2021)

The Role of Bcl-xL Protein in Viral Infections
por: Wyżewski, Zbigniew, et al.
Publicado: (2021)

Roles and Regulation of BCL-xL in Hematological Malignancies
por: Morales-Martínez, Mario, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mguh7s9eclsq5jg7tbre6682ah