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Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014205/ https://www.ncbi.nlm.nih.gov/pubmed/31941000 http://dx.doi.org/10.3390/ijms21020493 |
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author | Zhang, Xiao-Wen Chen, Jia-Yue Ouyang, Defang Lu, Jia-Hong |
author_facet | Zhang, Xiao-Wen Chen, Jia-Yue Ouyang, Defang Lu, Jia-Hong |
author_sort | Zhang, Xiao-Wen |
collection | PubMed |
description | Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wide range of plant species, is repeatedly reported to exert neuroprotective effects in experimental animal AD models. However, a systematic analysis of methodological rigor and the comparison between different studies is still lacking. A systematic review uses a methodical approach to minimize the bias in each independent study, providing a less biased, comprehensive understanding of research findings and an objective judgement of the strength of evidence and the reliability of conclusions. In this review, we identified 14 studies describing the therapeutic efficacy of quercetin on animal AD models by electronic and manual retrieval. Some of the results of the studies included were meta-analyzed by forest plot, and the methodological quality of each preclinical trial was assessed with SYRCLE’s risk of bias tool. Our results demonstrated the consistent neuroprotective effects of quercetin on different AD models, and the pharmacological mechanisms of quercetin on AD models are summarized. This information eliminated the bias of each individual study, providing guidance for future tests and supporting evidence for further implementation of quercetin into clinical trials. However, the limitations of some studies, such as the absence of sample size calculations and low method quality, should also be noted. |
format | Online Article Text |
id | pubmed-7014205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70142052020-03-09 Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies Zhang, Xiao-Wen Chen, Jia-Yue Ouyang, Defang Lu, Jia-Hong Int J Mol Sci Review Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wide range of plant species, is repeatedly reported to exert neuroprotective effects in experimental animal AD models. However, a systematic analysis of methodological rigor and the comparison between different studies is still lacking. A systematic review uses a methodical approach to minimize the bias in each independent study, providing a less biased, comprehensive understanding of research findings and an objective judgement of the strength of evidence and the reliability of conclusions. In this review, we identified 14 studies describing the therapeutic efficacy of quercetin on animal AD models by electronic and manual retrieval. Some of the results of the studies included were meta-analyzed by forest plot, and the methodological quality of each preclinical trial was assessed with SYRCLE’s risk of bias tool. Our results demonstrated the consistent neuroprotective effects of quercetin on different AD models, and the pharmacological mechanisms of quercetin on AD models are summarized. This information eliminated the bias of each individual study, providing guidance for future tests and supporting evidence for further implementation of quercetin into clinical trials. However, the limitations of some studies, such as the absence of sample size calculations and low method quality, should also be noted. MDPI 2020-01-13 /pmc/articles/PMC7014205/ /pubmed/31941000 http://dx.doi.org/10.3390/ijms21020493 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Xiao-Wen Chen, Jia-Yue Ouyang, Defang Lu, Jia-Hong Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title | Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_full | Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_fullStr | Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_full_unstemmed | Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_short | Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies |
title_sort | quercetin in animal models of alzheimer’s disease: a systematic review of preclinical studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014205/ https://www.ncbi.nlm.nih.gov/pubmed/31941000 http://dx.doi.org/10.3390/ijms21020493 |
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