Cargando…

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway

The constitutive activation of Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related to thyroid cancer and is considered to be a plausible therapeutic target. Hence, we investigated whether curcumin, a na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Abdul Q., Ahmed, Eiman I., Elareer, Noor, Fathima, Hamna, Prabhu, Kirti S., Siveen, Kodappully S., Kulinski, Michal, Azizi, Fouad, Dermime, Said, Ahmad, Aamir, Steinhoff, Martin, Uddin, Shahab
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014270/ https://www.ncbi.nlm.nih.gov/pubmed/31936675 http://dx.doi.org/10.3390/ijms21020438

Ejemplares similares

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia
por: Kuttikrishnan, Shilpa, et al.
Publicado: (2019)

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer
por: Siveen, Kodappully S., et al.
Publicado: (2019)

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
por: Prabhu, Kirti S., et al.
Publicado: (2020)

Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation
por: Siveen, Kodappully S., et al.
Publicado: (2019)

Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells
por: Khan, Abdul Q., et al.
Publicado: (2018)

Corrigendum: Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
por: Khan, Abdul Q., et al.
Publicado: (2023)

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
por: Akhtar, Sabah, et al.
Publicado: (2019)

Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines
por: Prabhu, Kirti S., et al.
Publicado: (2019)

Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species
por: Khan, Abdul Q., et al.
Publicado: (2020)

Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells
por: Iskandarani, Ahmad, et al.
Publicado: (2016)

Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin
por: Therachiyil, Lubna, et al.
Publicado: (2020)

Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products
por: Siveen, Kodappully S., et al.
Publicado: (2018)

TRPV2: A Cancer Biomarker and Potential Therapeutic Target
por: Siveen, Kodappully S., et al.
Publicado: (2020)

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
por: Prabhu, Kirti S., et al.
Publicado: (2018)

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells
por: Prabhu, Kirti S., et al.
Publicado: (2017)

Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies
por: Khan, Abdul Q., et al.
Publicado: (2019)

Targeting acute myeloid leukemia stem cell signaling by natural products
por: Siveen, Kodappully Sivaraman, et al.
Publicado: (2017)

Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells
por: Leo, Rari, et al.
Publicado: (2019)

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
por: Shailesh, Harshita, et al.
Publicado: (2021)

CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas
por: Ahmad, Aamir, et al.
Publicado: (2020)

Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells
por: Krishnankutty, Roopesh, et al.
Publicado: (2018)

Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
por: Khan, Abdul Q., et al.
Publicado: (2020)

Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatment: a case report
por: Merhi, Maysaloun, et al.
Publicado: (2020)

Phytochemicals in Cancer Prevention and Therapy
por: Pratheeshkumar, Poyil, et al.
Publicado: (2015)

Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
por: Akhtar, Sabah, et al.
Publicado: (2022)

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy
por: Raza, Afsheen, et al.
Publicado: (2020)

Editorial: LncRNAs in Cancer Metastasis and Therapy Resistance
por: Ahmad, Aamir, et al.
Publicado: (2021)

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
por: Maalej, Karama Makni, et al.
Publicado: (2023)

Potential therapeutic targets of Guggulsterone in cancer
por: Bhat, Ajaz A., et al.
Publicado: (2017)

Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells
por: Parasramka, Mansi A., et al.
Publicado: (2012)

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells
por: Rivera, Mariela, et al.
Publicado: (2017)

Proteomic Dissection of Exosome Cargo: Progress and Future Perspectives
por: Uddin, Shahab, et al.
Publicado: (2023)

Polymorphisms of selected Xenobiotic Genes contribute to the development of Papillary Thyroid Cancer susceptibility in Middle Eastern population
por: Siraj, Abdul K, et al.
Publicado: (2008)

Curcumin induces apoptosis in JAK2‐mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways
por: Petiti, Jessica, et al.
Publicado: (2019)

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity
por: Relecom, Allan, et al.
Publicado: (2021)

Erratum to “Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells”
por: Parasramka, Mansi A., et al.
Publicado: (2019)

Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties
por: Chimento, Adele, et al.
Publicado: (2023)

Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target
por: Fernandes, Queenie, et al.
Publicado: (2018)

Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line
por: Perna, Angelica, et al.
Publicado: (2018)

Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study
por: Sher, Gulab, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rcopk2d2s8uicnjghsuf4r5n7j