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Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the playe...

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Autores principales: Mongelli, Alessia, Atlante, Sandra, Bachetti, Tiziana, Martelli, Fabio, Farsetti, Antonella, Gaetano, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014325/
https://www.ncbi.nlm.nih.gov/pubmed/31941147
http://dx.doi.org/10.3390/ijms21020509
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author Mongelli, Alessia
Atlante, Sandra
Bachetti, Tiziana
Martelli, Fabio
Farsetti, Antonella
Gaetano, Carlo
author_facet Mongelli, Alessia
Atlante, Sandra
Bachetti, Tiziana
Martelli, Fabio
Farsetti, Antonella
Gaetano, Carlo
author_sort Mongelli, Alessia
collection PubMed
description RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.
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spelling pubmed-70143252020-03-09 Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases Mongelli, Alessia Atlante, Sandra Bachetti, Tiziana Martelli, Fabio Farsetti, Antonella Gaetano, Carlo Int J Mol Sci Review RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging. MDPI 2020-01-13 /pmc/articles/PMC7014325/ /pubmed/31941147 http://dx.doi.org/10.3390/ijms21020509 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mongelli, Alessia
Atlante, Sandra
Bachetti, Tiziana
Martelli, Fabio
Farsetti, Antonella
Gaetano, Carlo
Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
title Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
title_full Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
title_fullStr Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
title_full_unstemmed Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
title_short Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
title_sort epigenetic signaling and rna regulation in cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014325/
https://www.ncbi.nlm.nih.gov/pubmed/31941147
http://dx.doi.org/10.3390/ijms21020509
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