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MicroRNAs in Vascular Eye Diseases

Since the discovery of the first microRNA (miRNA) decades ago, studies of miRNA biology have expanded in many biomedical research fields, including eye research. The critical roles of miRNAs in normal development and diseases have made miRNAs useful biomarkers or molecular targets for potential ther...

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Detalles Bibliográficos
Autores principales: Liu, Chi-Hsiu, Huang, Shuo, Britton, William R., Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014392/
https://www.ncbi.nlm.nih.gov/pubmed/31963809
http://dx.doi.org/10.3390/ijms21020649
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author Liu, Chi-Hsiu
Huang, Shuo
Britton, William R.
Chen, Jing
author_facet Liu, Chi-Hsiu
Huang, Shuo
Britton, William R.
Chen, Jing
author_sort Liu, Chi-Hsiu
collection PubMed
description Since the discovery of the first microRNA (miRNA) decades ago, studies of miRNA biology have expanded in many biomedical research fields, including eye research. The critical roles of miRNAs in normal development and diseases have made miRNAs useful biomarkers or molecular targets for potential therapeutics. In the eye, ocular neovascularization (NV) is a leading cause of blindness in multiple vascular eye diseases. Current anti-angiogenic therapies, such as anti-vascular endothelial growth factor (VEGF) treatment, have their limitations, indicating the need for investigating new targets. Recent studies established the roles of various miRNAs in the regulation of pathological ocular NV, suggesting miRNAs as both biomarkers and therapeutic targets in vascular eye diseases. This review summarizes the biogenesis of miRNAs, and their functions in the normal development and diseases of the eye, with a focus on clinical and experimental retinopathies in both human and animal models. Discovery of novel targets involving miRNAs in vascular eye diseases will provide insights for developing new treatments to counter ocular NV.
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spelling pubmed-70143922020-03-09 MicroRNAs in Vascular Eye Diseases Liu, Chi-Hsiu Huang, Shuo Britton, William R. Chen, Jing Int J Mol Sci Review Since the discovery of the first microRNA (miRNA) decades ago, studies of miRNA biology have expanded in many biomedical research fields, including eye research. The critical roles of miRNAs in normal development and diseases have made miRNAs useful biomarkers or molecular targets for potential therapeutics. In the eye, ocular neovascularization (NV) is a leading cause of blindness in multiple vascular eye diseases. Current anti-angiogenic therapies, such as anti-vascular endothelial growth factor (VEGF) treatment, have their limitations, indicating the need for investigating new targets. Recent studies established the roles of various miRNAs in the regulation of pathological ocular NV, suggesting miRNAs as both biomarkers and therapeutic targets in vascular eye diseases. This review summarizes the biogenesis of miRNAs, and their functions in the normal development and diseases of the eye, with a focus on clinical and experimental retinopathies in both human and animal models. Discovery of novel targets involving miRNAs in vascular eye diseases will provide insights for developing new treatments to counter ocular NV. MDPI 2020-01-19 /pmc/articles/PMC7014392/ /pubmed/31963809 http://dx.doi.org/10.3390/ijms21020649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Chi-Hsiu
Huang, Shuo
Britton, William R.
Chen, Jing
MicroRNAs in Vascular Eye Diseases
title MicroRNAs in Vascular Eye Diseases
title_full MicroRNAs in Vascular Eye Diseases
title_fullStr MicroRNAs in Vascular Eye Diseases
title_full_unstemmed MicroRNAs in Vascular Eye Diseases
title_short MicroRNAs in Vascular Eye Diseases
title_sort micrornas in vascular eye diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014392/
https://www.ncbi.nlm.nih.gov/pubmed/31963809
http://dx.doi.org/10.3390/ijms21020649
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