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Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury

The purpose of this study was to analyze changes in the levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-β1 (TGF-β1) in response to strength recovery after eccentric exercise in humans. In this study, 16 healthy males part...

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Detalles Bibliográficos
Autores principales: Kim, Jooyoung, Lee, Joohyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014421/
https://www.ncbi.nlm.nih.gov/pubmed/31963105
http://dx.doi.org/10.3390/ijerph17020566
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author Kim, Jooyoung
Lee, Joohyung
author_facet Kim, Jooyoung
Lee, Joohyung
author_sort Kim, Jooyoung
collection PubMed
description The purpose of this study was to analyze changes in the levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-β1 (TGF-β1) in response to strength recovery after eccentric exercise in humans. In this study, 16 healthy males participated and were divided into a faster recovery (FR) group (n = 8, >80% of baseline) and a slower recovery (SR) group (n = 8, <40% of baseline) on the basis of their recovery of maximal isometric strength (MIS) 96 h after eccentric exercise. For both groups, measurements were taken of muscle soreness, creatine kinase (CK) activity, and MMP-9, TIMP-1, and TGF-β1 levels during the 24- to 96-h period after eccentric muscle contraction of their non-dominant elbow flexor. Muscle soreness (p < 0.001), CK activity (p < 0.01), and TGF-β1 level (p < 0.01) were significantly lower in the FR group compared with SR group, whereas no significant differences in MMP-9 and TIMP-1 levels were found between the two groups (p > 0.05). These results suggest that scar tissue formation caused by the pro-fibrotic activity of growth factors such as TGF-β1 is a potential cause of delay in strength recovery after exercise-induced muscle injury.
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spelling pubmed-70144212020-03-09 Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury Kim, Jooyoung Lee, Joohyung Int J Environ Res Public Health Article The purpose of this study was to analyze changes in the levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-β1 (TGF-β1) in response to strength recovery after eccentric exercise in humans. In this study, 16 healthy males participated and were divided into a faster recovery (FR) group (n = 8, >80% of baseline) and a slower recovery (SR) group (n = 8, <40% of baseline) on the basis of their recovery of maximal isometric strength (MIS) 96 h after eccentric exercise. For both groups, measurements were taken of muscle soreness, creatine kinase (CK) activity, and MMP-9, TIMP-1, and TGF-β1 levels during the 24- to 96-h period after eccentric muscle contraction of their non-dominant elbow flexor. Muscle soreness (p < 0.001), CK activity (p < 0.01), and TGF-β1 level (p < 0.01) were significantly lower in the FR group compared with SR group, whereas no significant differences in MMP-9 and TIMP-1 levels were found between the two groups (p > 0.05). These results suggest that scar tissue formation caused by the pro-fibrotic activity of growth factors such as TGF-β1 is a potential cause of delay in strength recovery after exercise-induced muscle injury. MDPI 2020-01-16 2020-01 /pmc/articles/PMC7014421/ /pubmed/31963105 http://dx.doi.org/10.3390/ijerph17020566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Jooyoung
Lee, Joohyung
Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
title Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
title_full Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
title_fullStr Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
title_full_unstemmed Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
title_short Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
title_sort plasma mmp-9, timp-1, and tgf-β1 responses to exercise-induced muscle injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014421/
https://www.ncbi.nlm.nih.gov/pubmed/31963105
http://dx.doi.org/10.3390/ijerph17020566
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