Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats

Objective: This study was conducted to evaluate the acute and subchronic toxicity of gardenia yellow, a natural colorant widely used in China and other Asian countries. An acute toxicity test was performed in S-D rats of both genders and the lethal dose (LD(50)) of per oral gardenia yellow was estim...

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Autores principales: Tang, Xiaoqiao, Wang, Yangfeng, Yang, Wenxiang, Zheng, Yanhua, Liu, Chunxia, Qu, Min, Xu, Haibin, Zhang, Lei, Liang, Jiang, Fan, Bolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014442/
https://www.ncbi.nlm.nih.gov/pubmed/31947699
http://dx.doi.org/10.3390/ijerph17020531
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author Tang, Xiaoqiao
Wang, Yangfeng
Yang, Wenxiang
Zheng, Yanhua
Liu, Chunxia
Qu, Min
Xu, Haibin
Zhang, Lei
Liang, Jiang
Fan, Bolin
author_facet Tang, Xiaoqiao
Wang, Yangfeng
Yang, Wenxiang
Zheng, Yanhua
Liu, Chunxia
Qu, Min
Xu, Haibin
Zhang, Lei
Liang, Jiang
Fan, Bolin
author_sort Tang, Xiaoqiao
collection PubMed
description Objective: This study was conducted to evaluate the acute and subchronic toxicity of gardenia yellow, a natural colorant widely used in China and other Asian countries. An acute toxicity test was performed in S-D rats of both genders and the lethal dose (LD(50)) of per oral gardenia yellow was estimated to be more than 15.0 g/kg·bw. In the subchronic study, gardenia yellow was orally administered to rats by gavage at doses of 0, 0.50, 1.50 and 4.50 g/kg·bw/day for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 0.50 g/kg·bw/day group. When the animals received gardenia yellow at 1.50 g/kg·bw/day or more, body weight loss was observed, and pigments began to deposit in several vital organs, resulting in significant changes of several hematological and biochemical indicators related to the nutritional status of the body, liver and kidney function, more severe in the high dose group. In the recovery period, the alterations of the clinical symptoms and parameters were relieved a lot. Based on the results of the current study, the no observed adverse effect level (NOAEL) of gardenia yellow E500 in rats was set to be 0.50 g/kg·bw/day.
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spelling pubmed-70144422020-03-09 Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats Tang, Xiaoqiao Wang, Yangfeng Yang, Wenxiang Zheng, Yanhua Liu, Chunxia Qu, Min Xu, Haibin Zhang, Lei Liang, Jiang Fan, Bolin Int J Environ Res Public Health Article Objective: This study was conducted to evaluate the acute and subchronic toxicity of gardenia yellow, a natural colorant widely used in China and other Asian countries. An acute toxicity test was performed in S-D rats of both genders and the lethal dose (LD(50)) of per oral gardenia yellow was estimated to be more than 15.0 g/kg·bw. In the subchronic study, gardenia yellow was orally administered to rats by gavage at doses of 0, 0.50, 1.50 and 4.50 g/kg·bw/day for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 0.50 g/kg·bw/day group. When the animals received gardenia yellow at 1.50 g/kg·bw/day or more, body weight loss was observed, and pigments began to deposit in several vital organs, resulting in significant changes of several hematological and biochemical indicators related to the nutritional status of the body, liver and kidney function, more severe in the high dose group. In the recovery period, the alterations of the clinical symptoms and parameters were relieved a lot. Based on the results of the current study, the no observed adverse effect level (NOAEL) of gardenia yellow E500 in rats was set to be 0.50 g/kg·bw/day. MDPI 2020-01-14 2020-01 /pmc/articles/PMC7014442/ /pubmed/31947699 http://dx.doi.org/10.3390/ijerph17020531 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tang, Xiaoqiao
Wang, Yangfeng
Yang, Wenxiang
Zheng, Yanhua
Liu, Chunxia
Qu, Min
Xu, Haibin
Zhang, Lei
Liang, Jiang
Fan, Bolin
Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats
title Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats
title_full Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats
title_fullStr Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats
title_full_unstemmed Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats
title_short Acute and Subchronic Oral Toxicity Study of Gardenia Yellow E500 in Sprague-Dawley Rats
title_sort acute and subchronic oral toxicity study of gardenia yellow e500 in sprague-dawley rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014442/
https://www.ncbi.nlm.nih.gov/pubmed/31947699
http://dx.doi.org/10.3390/ijerph17020531
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